Oxygen free radicals have been implicated in the pathogenesis of postischemic liver injury. High-dose superoxide dismutase (SOD), a radical scavenging enzyme, has been investigated in a rat model of liver ischemia reperfusion by biochemical monitoring. Blood vessels to the median and left lobe were clamped for 1 h and then reperfusion was allowed. The indices used were serial venous blood levels of AST, ALT, calcium, and ATP determination in liver tissue. In SOD-treated animals (7,5000 U i.v.) a significant attenuation of the rise in enzyme levels was observed as well as the absence of the decrease in calcium level in the early phase after reperfusion as compared with control rats, and furthermore ATP restoration was significantly increased.

Effect of superoxide dismutase on liver ischemia-reperfusion injury in the rat: A biochemical monitoring / F. Romani, M. Vertemati, M. Frangi, P. Aseni, R. Monti, A. Codeghini, L. Belli. - In: EUROPEAN SURGICAL RESEARCH. - ISSN 0014-312X. - 20:5-6(1988), pp. 335-340.

Effect of superoxide dismutase on liver ischemia-reperfusion injury in the rat: A biochemical monitoring

M. Vertemati;M. Frangi;
1988

Abstract

Oxygen free radicals have been implicated in the pathogenesis of postischemic liver injury. High-dose superoxide dismutase (SOD), a radical scavenging enzyme, has been investigated in a rat model of liver ischemia reperfusion by biochemical monitoring. Blood vessels to the median and left lobe were clamped for 1 h and then reperfusion was allowed. The indices used were serial venous blood levels of AST, ALT, calcium, and ATP determination in liver tissue. In SOD-treated animals (7,5000 U i.v.) a significant attenuation of the rise in enzyme levels was observed as well as the absence of the decrease in calcium level in the early phase after reperfusion as compared with control rats, and furthermore ATP restoration was significantly increased.
Settore BIO/16 - Anatomia Umana
Settore MED/18 - Chirurgia Generale
Settore BIO/10 - Biochimica
1988
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/702188
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