Hypoxia, or lack of oxygen, can occur in both physiological (high altitude) and pathological conditions (respiratory diseases). In this narrative review, we introduce high altitude pulmonary edema (HAPE), acute respiratory distress syndrome (ARDS), Chronic Obstructive Pulmonary Disease (COPD), and Cystic Fibrosis (CF) as examples of maladaptation to hypoxia, and highlight some of the potential mechanisms influencing the prognosis of the affected patients. Among the specific pathways modulated in response to hypoxia, iron metabolism has been widely explored in recent years. Recent evidence emphasizes hepcidin as highly involved in the compensatory response to hypoxia in healthy subjects. A less investigated field in the adaptation to hypoxia is the sphingolipid (SPL) metabolism, especially through Ceramide and sphingosine 1 phosphate. Both individually and in concert, iron and SPL are active players of the (mal)adaptation to physiological hypoxia, which can result in the pathological HAPE. Our aim is to identify some pathways and/or markers involved in the physiological adaptation to low atmospheric pressures (high altitudes) that could be involved in pathological adaptation to hypoxia as it occurs in pulmonary inflammatory diseases. Hepcidin, Cer, S1P, and their interplay in hypoxia are raising growing interest both as prognostic factors and therapeutical targets.
Iron and Sphingolipids as Common Players of (Mal)Adaptation to Hypoxia in Pulmonary Diseases / S. Ottolenghi, A. Zulueta, A. Caretti. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1422-0067. - 21:1(2020 Jan 02), pp. 307.1-307.18.
|Titolo:||Iron and Sphingolipids as Common Players of (Mal)Adaptation to Hypoxia in Pulmonary Diseases|
OTTOLENGHI, SARA (Primo) (Corresponding)
ZULUETA MORALES, AIDA (Secondo)
CARETTI, ANNA (Ultimo)
|Parole Chiave:||hypoxia; iron; sphingolipids; hepcidin; ceramide; adaptation; COPD; Cystic Fibrosis; ARDS|
|Settore Scientifico Disciplinare:||Settore BIO/13 - Biologia Applicata|
Settore BIO/10 - Biochimica
Settore MED/10 - Malattie dell'Apparato Respiratorio
|Data di pubblicazione:||2-gen-2020|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.3390/ijms21010307|
|Appare nelle tipologie:||01 - Articolo su periodico|