A novel, highly stereoselective route for pharmaceutically relevant octahydroindole-2-carboxylates bearing a quaternary stereocenter has been developed. The key chiral intermediates 3 have been prepared in good yields and enantiomeric excesses up to 98%. A broad substrate range has been tolerated under the reaction conditions.
Stereoselective Michael additions on α-aminoacrylates as the key step to an L-Oic analogue bearing a quaternary stereocenter / F.M. Cecchinelli, G. Celentano, A. Puglisi, N. Gaggero. - In: ORGANIC & BIOMOLECULAR CHEMISTRY. - ISSN 1477-0520. - 18:4(2020 Jan 28), pp. 671-674. [10.1039/c9ob02084e]
Stereoselective Michael additions on α-aminoacrylates as the key step to an L-Oic analogue bearing a quaternary stereocenter
G. CelentanoSecondo
;A. PuglisiPenultimo
;N. Gaggero
Ultimo
2020
Abstract
A novel, highly stereoselective route for pharmaceutically relevant octahydroindole-2-carboxylates bearing a quaternary stereocenter has been developed. The key chiral intermediates 3 have been prepared in good yields and enantiomeric excesses up to 98%. A broad substrate range has been tolerated under the reaction conditions.File | Dimensione | Formato | |
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