3,3-Disubstituted oxindole derivatives bearing a nitrogen atom at the C-3 position have been synthesized starting from 3-alkyl oxindole through a metal free pathway. These derivatives have been tested in five human tumor cell lines (PC3, MCF7, SW620, MiaPaca2 and A375) and on primary cells (PBMCs) from healthy donors providing compound 6d showing a strong anticancer effect in all cancer lines on the low micromolar range.
Novel 3,3-disubstituted oxindole derivatives. Synthesis and evaluation of the anti-proliferative activity / M. Christodoulou, F. Nicoletti, K. Mangano, M.A. Chiacchio, G. Facchetti, I. Rimoldi, E.M. Beccalli, S. Giofrè. - In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - ISSN 0960-894X. - 30:2(2020 Jan 15). [10.1016/j.bmcl.2019.126845]
Novel 3,3-disubstituted oxindole derivatives. Synthesis and evaluation of the anti-proliferative activity
M. ChristodoulouPrimo
;G. Facchetti;I. Rimoldi;E.M. Beccalli
Penultimo
;S. GiofrèUltimo
2020
Abstract
3,3-Disubstituted oxindole derivatives bearing a nitrogen atom at the C-3 position have been synthesized starting from 3-alkyl oxindole through a metal free pathway. These derivatives have been tested in five human tumor cell lines (PC3, MCF7, SW620, MiaPaca2 and A375) and on primary cells (PBMCs) from healthy donors providing compound 6d showing a strong anticancer effect in all cancer lines on the low micromolar range.
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