3,3-Disubstituted oxindole derivatives bearing a nitrogen atom at the C-3 position have been synthesized starting from 3-alkyl oxindole through a metal free pathway. These derivatives have been tested in five human tumor cell lines (PC3, MCF7, SW620, MiaPaca2 and A375) and on primary cells (PBMCs) from healthy donors providing compound 6d showing a strong anticancer effect in all cancer lines on the low micromolar range.
Novel 3,3-disubstituted oxindole derivatives. Synthesis and evaluation of the anti-proliferative activity / M. Christodoulou, F. Nicoletti, K. Mangano, M.A. Chiacchio, G. Facchetti, I. Rimoldi, E.M. Beccalli, S. Giofrè. - In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - ISSN 0960-894X. - 30:2(2020 Jan 15).
Titolo: | Novel 3,3-disubstituted oxindole derivatives. Synthesis and evaluation of the anti-proliferative activity |
Autori: | CHRISTODOULOU, MICHAIL (Primo) GIOFRE', SABRINA (Ultimo) |
Parole Chiave: | 3,3-Disubstituted oxindole; Anti-proliferative activity; Human cancer cell lines; Iminophosphorane; Isocyanate; |
Settore Scientifico Disciplinare: | Settore CHIM/06 - Chimica Organica Settore CHIM/08 - Chimica Farmaceutica |
Progetto: | PIANO DI SOSTEGNO ALLA RICERCA 2015-2017 - LINEA 2 "DOTAZIONE ANNUALE PER ATTIVITA' ISTITUZIONALE" |
Data di pubblicazione: | 15-gen-2020 |
Rivista: | |
Tipologia: | Article (author) |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.bmcl.2019.126845 |
Appare nelle tipologie: | 01 - Articolo su periodico |
File in questo prodotto:
File | Descrizione | Tipologia | Licenza | |
---|---|---|---|---|
Manuscript-pre print.pdf | Pre-print (manoscritto inviato all'editore) | Open Access Visualizza/Apri | ||
1-s2.0-S0960894X19308194-main.pdf | Publisher's version/PDF | Administrator Richiedi una copia |