OBJECTIVE. The purpose of this article is to describe the risk-benefit balance of contrast-enhanced breast MRI (CE-BMRI) screening. CONCLUSION. CE-BMRI confers risk of effects associated with administration of gadolinium-based contrast agents (GBCAs), including nephrogenic systemic fibrosis and gadolinium retention. The risk-benefit balance of CE-BMRI screening is favorable for carriers of BRCA, TP53, or other deleterious mutations women who have undergone thoracic irradiation; and women at 20% or greater lifetime risk of breast cancer. The balance is uncertain, however, for women at intermediate to average risk. Women must always receive detailed information regarding possible GBCA-associated effects.

Gadolinium Retention and Breast MRI Screening : More Harm Than Good? / F. Sardanelli, A. Cozzi, R.M. Trimboli, S. Schiaffino. - In: AMERICAN JOURNAL OF ROENTGENOLOGY. - ISSN 0361-803X. - 214:2(2020 Feb), pp. 324-327.

Gadolinium Retention and Breast MRI Screening : More Harm Than Good?

F. Sardanelli
Primo
;
A. Cozzi
Secondo
;
R.M. Trimboli
Penultimo
;
2020-02

Abstract

OBJECTIVE. The purpose of this article is to describe the risk-benefit balance of contrast-enhanced breast MRI (CE-BMRI) screening. CONCLUSION. CE-BMRI confers risk of effects associated with administration of gadolinium-based contrast agents (GBCAs), including nephrogenic systemic fibrosis and gadolinium retention. The risk-benefit balance of CE-BMRI screening is favorable for carriers of BRCA, TP53, or other deleterious mutations women who have undergone thoracic irradiation; and women at 20% or greater lifetime risk of breast cancer. The balance is uncertain, however, for women at intermediate to average risk. Women must always receive detailed information regarding possible GBCA-associated effects.
MRI; breast neoplasms; contrast media; gadolinium; nephrogenic systemic fibrosis
Settore MED/36 - Diagnostica per Immagini e Radioterapia
4-dic-2019
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/699364
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