OBJECTIVE. The purpose of this article is to describe the risk-benefit balance of contrast-enhanced breast MRI (CE-BMRI) screening. CONCLUSION. CE-BMRI confers risk of effects associated with administration of gadolinium-based contrast agents (GBCAs), including nephrogenic systemic fibrosis and gadolinium retention. The risk-benefit balance of CE-BMRI screening is favorable for carriers of BRCA, TP53, or other deleterious mutations women who have undergone thoracic irradiation; and women at 20% or greater lifetime risk of breast cancer. The balance is uncertain, however, for women at intermediate to average risk. Women must always receive detailed information regarding possible GBCA-associated effects.
Gadolinium Retention and Breast MRI Screening : More Harm Than Good? / F. Sardanelli, A. Cozzi, R.M. Trimboli, S. Schiaffino. - In: AMERICAN JOURNAL OF ROENTGENOLOGY. - ISSN 0361-803X. - 214:2(2020 Feb), pp. 324-327.
Gadolinium Retention and Breast MRI Screening : More Harm Than Good?
F. Sardanelli
Primo
;A. CozziSecondo
;R.M. TrimboliPenultimo
;
2020
Abstract
OBJECTIVE. The purpose of this article is to describe the risk-benefit balance of contrast-enhanced breast MRI (CE-BMRI) screening. CONCLUSION. CE-BMRI confers risk of effects associated with administration of gadolinium-based contrast agents (GBCAs), including nephrogenic systemic fibrosis and gadolinium retention. The risk-benefit balance of CE-BMRI screening is favorable for carriers of BRCA, TP53, or other deleterious mutations women who have undergone thoracic irradiation; and women at 20% or greater lifetime risk of breast cancer. The balance is uncertain, however, for women at intermediate to average risk. Women must always receive detailed information regarding possible GBCA-associated effects.Pubblicazioni consigliate
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