Interest in orodispersible films (ODF) is growing day-by-day, since this dosage form overcomes some therapeutic obstacles, such as impaired swallowing, and offers several benefits, such as the possibility to adapt the dosing requirements for a subset of patients. As a consequence, technologies to produce ODF have risen attention for possible applications in the development of patient-centric formulations. This review critically discusses current trends in the technology platforms proposed to manufacture ODF, including the innovation and opportunities to produce very small batches in a pharmacy setting. Although the main Pharmacopoeias recommend testing customized dosage forms for quality assurance, pharmaceutical assays are a matter of debate due to the complexity and high cost of conventional methods. Alternatively, non-disruptive online analytic methods can be proposed to assay ODF properties, above all to assure the uniformity of drug content.
Trends in the production methods of orodispersible films / U.M. Musazzi, G.M. Khalid, F. Selmin, P. Minghetti, F. Cilurzo. - In: INTERNATIONAL JOURNAL OF PHARMACEUTICS. - ISSN 0378-5173. - 576(2020 Feb 25), pp. 118963.1-118963.10.
|Titolo:||Trends in the production methods of orodispersible films|
CILURZO, FRANCESCO (Corresponding)
|Parole Chiave:||drug printing; flexographic printing; individualized medicine; orodispersible films; solvent casting|
|Settore Scientifico Disciplinare:||Settore CHIM/09 - Farmaceutico Tecnologico Applicativo|
|Data di pubblicazione:||25-feb-2020|
|Data ahead of print / Data di stampa:||16-dic-2019|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.ijpharm.2019.118963|
|Appare nelle tipologie:||01 - Articolo su periodico|