Two crystalline modifications of LR-B 0/81, a new antihypertensive molecule, have been detected and characterized by various solid state analytical techniques such as DSC, FT-IR Thermomicroscopy, XRD and SEM. Form I, the most stable one, has a melting point of 177°C whereas form II melts at 144°C. The system is related monotropically, as demonstrated by the results of micronization and heating experiments. Since dissolution rates of the two crystal forms are very similar, polymorphism do not affect bioavailability of solid dosage form.

Analytical profile of polymorphism of LR-B 0/81 / D. Notarangelo, P. Ghetti, R. Stradi, A. Salimbeni, E. Pini. - In: BOLLETTINO CHIMICO FARMACEUTICO. - ISSN 0006-6648. - 136:5(1997), pp. 474-481.

Analytical profile of polymorphism of LR-B 0/81

R. Stradi
Membro del Collaboration Group
;
E. Pini
Ultimo
Membro del Collaboration Group
1997

Abstract

Two crystalline modifications of LR-B 0/81, a new antihypertensive molecule, have been detected and characterized by various solid state analytical techniques such as DSC, FT-IR Thermomicroscopy, XRD and SEM. Form I, the most stable one, has a melting point of 177°C whereas form II melts at 144°C. The system is related monotropically, as demonstrated by the results of micronization and heating experiments. Since dissolution rates of the two crystal forms are very similar, polymorphism do not affect bioavailability of solid dosage form.
antihypertensive drug; DSC; IR; micronization; polymorphism; stability relationship; XRD
Settore CHIM/06 - Chimica Organica
1997
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/697910
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