In the present review, associations between traditional vascular risk factors (VRFs) and carotid intima-medial thickness progression (C-IMTp) as well as the effects of therapies for VRFs control on C-IMTp were appraised to infer causality between each VRF and C-IMTp. Cohort studies indicate that smoking, binge drinking, fatness, diabetes, hypertension and hypercholesterolemia are associated with accelerated C-IMTp. An exception is physical activity, with mixed data. Interventions for the control of obesity, diabetes, hypertension and hypercholesterolemia decelerate C-IMTp. Conversely, scarce information is available regarding the effect of smoking cessation, stop of excessive alcohol intake and management of the metabolic syndrome. Altogether, these data support a causative role of several traditional VRFs on C-IMTp. Shortcomings in study design and/or ultrasonographic protocols may account for most negative studies, which underlines the importance of a careful consideration of methodological aspects in investigations using C-IMTp as the outcome.
|Titolo:||Traditional Risk Factors are Causally Related to Carotid Intima-Media Thickness Progression : Inferences from Observational Cohort Studies and Interventional Trials|
BALDASSARRE, DAMIANO (Ultimo) (Corresponding)
|Parole Chiave:||Atherosclerosis; Atherosclerosis Progression; Carotid Intima-Medial Thickness; Causality; Risk Factors; Ultrasonography|
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
|Data di pubblicazione:||2020|
|Digital Object Identifier (DOI):||10.2174/1381612825666191213120339|
|Appare nelle tipologie:||01 - Articolo su periodico|