In the present review, associations between traditional vascular risk factors (VRFs) and carotid intima-medial thickness progression (C-IMTp) as well as the effects of therapies for VRFs control on C-IMTp were appraised to infer causality between each VRF and C-IMTp. Cohort studies indicate that smoking, binge drinking, fatness, diabetes, hypertension and hypercholesterolemia are associated with accelerated C-IMTp. An exception is physical activity, with mixed data. Interventions for the control of obesity, diabetes, hypertension and hypercholesterolemia decelerate C-IMTp. Conversely, scarce information is available regarding the effect of smoking cessation, stop of excessive alcohol intake and management of the metabolic syndrome. Altogether, these data support a causative role of several traditional VRFs on C-IMTp. Shortcomings in study design and/or ultrasonographic protocols may account for most negative studies, which underlines the importance of a careful consideration of methodological aspects in investigations using C-IMTp as the outcome.

Traditional Risk Factors are Causally Related to Carotid Intima-Media Thickness Progression : Inferences from Observational Cohort Studies and Interventional Trials / B. Frigerio, J.P. Werba, M. Amato, A. Ravani, D. Sansaro, D. Coggi, L. Vigo, E. Tremoli, D. Baldassarre. - In: CURRENT PHARMACEUTICAL DESIGN. - ISSN 1381-6128. - 26(2020), pp. 1-14. [Epub ahead of print] [10.2174/1381612825666191213120339]

Traditional Risk Factors are Causally Related to Carotid Intima-Media Thickness Progression : Inferences from Observational Cohort Studies and Interventional Trials

D. Coggi;E. Tremoli;D. Baldassarre
Ultimo
2020

Abstract

In the present review, associations between traditional vascular risk factors (VRFs) and carotid intima-medial thickness progression (C-IMTp) as well as the effects of therapies for VRFs control on C-IMTp were appraised to infer causality between each VRF and C-IMTp. Cohort studies indicate that smoking, binge drinking, fatness, diabetes, hypertension and hypercholesterolemia are associated with accelerated C-IMTp. An exception is physical activity, with mixed data. Interventions for the control of obesity, diabetes, hypertension and hypercholesterolemia decelerate C-IMTp. Conversely, scarce information is available regarding the effect of smoking cessation, stop of excessive alcohol intake and management of the metabolic syndrome. Altogether, these data support a causative role of several traditional VRFs on C-IMTp. Shortcomings in study design and/or ultrasonographic protocols may account for most negative studies, which underlines the importance of a careful consideration of methodological aspects in investigations using C-IMTp as the outcome.
Atherosclerosis; Atherosclerosis Progression; Carotid Intima-Medial Thickness; Causality; Risk Factors; Ultrasonography
Settore BIO/14 - Farmacologia
2020
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/697564
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