The present invention provides a new type of lipid nanoparticles comprising amphiphilic lipids suitable for the incorporation of peptides and/or proteins, in order to provide their controlled release, once they have been administered. In particular, the main object of the invention is to provide a new type of lipid nanoparticles comprising a drug, a lipid matrix and a surfactant characterized in that said drug is a peptide or a protein and said lipid matrix has a monoglyceride content which is at least 70% w/w, the percentage being based on the weight of the lipid matrix.
Amphiphilic lipid nanoparticles for peptide and/or protein incorporation / M. Del Curto, D. Chicco, E. Esposito.
Amphiphilic lipid nanoparticles for peptide and/or protein incorporation
M. Del CurtoPrimo
;
2002
Abstract
The present invention provides a new type of lipid nanoparticles comprising amphiphilic lipids suitable for the incorporation of peptides and/or proteins, in order to provide their controlled release, once they have been administered. In particular, the main object of the invention is to provide a new type of lipid nanoparticles comprising a drug, a lipid matrix and a surfactant characterized in that said drug is a peptide or a protein and said lipid matrix has a monoglyceride content which is at least 70% w/w, the percentage being based on the weight of the lipid matrix.
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