lung transplantation (LuTX) is a consolidated surgical therapy of end-stage pulmonary failure when maximal medical therapy fails. To assess the quality of the graft of the donor, chest x-ray, arterial gas analysis and smoking history are currently used, but often these factors do not allow a proper evaluation of the real cellular damage. In the donor, aspiration of gastric content, brain-death, or initial intensive care infections affect transplant outcome especially in the first 72 hours. Furthermore, ischemia-reperfusion lung injury (IRI) has a key role in the development of primary grafts dysfunction (PGD).
Extracellular vescicles and lung transplantation: new prospective in the evaluation of injury and function of the graft / I. Righi, L. Lazzari, M. Barilani, G. Buono, C. Diotti, F. Damarco, M. Nosotti, L. Rosso. - In: TRANSPLANT INTERNATIONAL. - ISSN 0934-0874. - 32:suppl. 2(2019), pp. 247-247. ((Intervento presentato al 19. convegno ESOT Congress tenutosi a Copenhagen nel 2019.
Extracellular vescicles and lung transplantation: new prospective in the evaluation of injury and function of the graft
C. Diotti;M. Nosotti;L. Rosso
2019
Abstract
lung transplantation (LuTX) is a consolidated surgical therapy of end-stage pulmonary failure when maximal medical therapy fails. To assess the quality of the graft of the donor, chest x-ray, arterial gas analysis and smoking history are currently used, but often these factors do not allow a proper evaluation of the real cellular damage. In the donor, aspiration of gastric content, brain-death, or initial intensive care infections affect transplant outcome especially in the first 72 hours. Furthermore, ischemia-reperfusion lung injury (IRI) has a key role in the development of primary grafts dysfunction (PGD).File | Dimensione | Formato | |
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