Background: The interest in donation after cardiocirculatory death (DCD) donors for lung transplantation (LT) has been recently rekindled due to lung allograft shortage. Clinical outcomes following DCD have proved satisfactory. The aim of this systematic review is to provide a thorough analysis of published experience regarding outcomes of LT after controlled DCD compared with donation after brain death (DBD) donors. Methods: We performed a literature search in Cochrane Database of Systematic Reviews, PubMed and Web of Science using the items "lung transplantation" AND "donation after circulatory death" on November 1, 2018. The full text of relevant articles was evaluated by two authors independently. Quality assessment was performed using the NIH protocol for case-control and case series studies. A pooled Odds ratio (OR) and mean differences with inverse variance weighting using DerSimonian-Laird random effect models were computed to account for between-trial variance (tau 2). Results: Of the 508 articles identified with our search, 9 regarding controlled donation after cardiac death (cDCD) were included in the systematic review, including 2973 patients (403 who received graft from DCD and 2570 who had DBD). Both 1-year survival and 2 and 3-grade primary graft dysfunction (PGD) were balanced between the two cohorts (OR = 1.00 and 1.03 respectively); OR for airway complications was 2.07 against cDCD. We also report an OR = 0.57 for chronic lung allograft dysfunction (CLAD) and an OR = 0.57 for 5-year survival against cDCD. Conclusions: Our meta-analysis shows no significant difference between recipients after cDCD or DBD regarding 1-year survival, PGD and 1-year freedom from CLAD. Airway complications and long-term survival were both related with transplantation after cDCD, but these statistical associations need further research.
Lung transplantation from donation after controlled cardiocirculatory death: Systematic review and meta-analysis / A. Palleschi, L. Rosso, V. Musso, A. Rimessi, G. Bonitta, M. Nosotti. - In: TRANSPLANTATION REVIEWS. - ISSN 0955-470X. - 34:1(2020 Jan), p. 100513.100513.
|Titolo:||Lung transplantation from donation after controlled cardiocirculatory death: Systematic review and meta-analysis|
ROSSO, LORENZO PAOLO ANTONIO (Secondo)
MUSSO, VALERIA (Corresponding)
NOSOTTI, MARIO (Ultimo)
|Settore Scientifico Disciplinare:||Settore MED/21 - Chirurgia Toracica|
|Data di pubblicazione:||gen-2020|
|Data ahead of print / Data di stampa:||ott-2019|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.trre.2019.100513|
|Appare nelle tipologie:||01 - Articolo su periodico|