The tumor microenvironment (TME) is an attractive target to develop novel strategies for hormone-dependent cancers. Several molecules in the TME can favor tumor development and progression, including lipoproteins. Lipoproteins are taken up by cancer cells providing them with cholesterol and fatty acids. Cholesterol regulates cell signaling and it is converted into a series of bioactive metabolites, including hormones. The conflicting results of epidemiological and interventional studies suggest that the local availability of lipoproteins in the TME is more relevant for cancer biology than their circulating levels. Thus, reducing lipoprotein uptake and stimulating cell cholesterol efflux to high density lipoproteins (HDL) can represent a novel adjuvant strategy for cancer management. HDL-like particles can also act as drug delivery systems for tumor targeting.
Role of lipoproteins in the microenvironment of hormone-dependent cancers / M. Gomaraschi. - In: TRENDS IN ENDOCRINOLOGY AND METABOLISM. - ISSN 1043-2760. - 31:3(2020 Mar), pp. 256-268.
Role of lipoproteins in the microenvironment of hormone-dependent cancers
M. Gomaraschi
Ultimo
2020
Abstract
The tumor microenvironment (TME) is an attractive target to develop novel strategies for hormone-dependent cancers. Several molecules in the TME can favor tumor development and progression, including lipoproteins. Lipoproteins are taken up by cancer cells providing them with cholesterol and fatty acids. Cholesterol regulates cell signaling and it is converted into a series of bioactive metabolites, including hormones. The conflicting results of epidemiological and interventional studies suggest that the local availability of lipoproteins in the TME is more relevant for cancer biology than their circulating levels. Thus, reducing lipoprotein uptake and stimulating cell cholesterol efflux to high density lipoproteins (HDL) can represent a novel adjuvant strategy for cancer management. HDL-like particles can also act as drug delivery systems for tumor targeting.File | Dimensione | Formato | |
---|---|---|---|
pdf AIR.pdf
accesso aperto
Descrizione: articolo principale
Tipologia:
Pre-print (manoscritto inviato all'editore)
Dimensione
322.78 kB
Formato
Adobe PDF
|
322.78 kB | Adobe PDF | Visualizza/Apri |
1-s2.0-S1043276019302279-main.pdf
accesso riservato
Tipologia:
Publisher's version/PDF
Dimensione
1.27 MB
Formato
Adobe PDF
|
1.27 MB | Adobe PDF | Visualizza/Apri Richiedi una copia |
1-s2.0-S1043276019302279-main.pdf
accesso riservato
Tipologia:
Publisher's version/PDF
Dimensione
1.32 MB
Formato
Adobe PDF
|
1.32 MB | Adobe PDF | Visualizza/Apri Richiedi una copia |
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.