Autoantibodies (AAbs) are a hallmark of Type 1 diabetes (T1D). Alterations in the frequency and phenotype of follicular helper (Tfh) T cells have been previously documented in patients with type 1 diabetes (T1D), but the contribution of follicular Treg cells, which are responsible for suppressing AAb development, is less clear. Here, we investigated the frequency and activation status of follicular (CXCR5+) and CXCR5- Treg cells in the blood of children with new onset T1D and children with risk for developing T1D (AAb-positive) and compared them to AAb-negative controls. Blood CXCR5+ and CXCR5- Treg cells were higher in frequency children with new onset T1D and expressed reduced amounts of PD-1 as compared to controls. Interestingly, the proportion of circulating FOXP3+ Tregs expressing PD-1 was also reduced in AAb-positive at-risk children as compared to controls, suggesting its potential use as a biomarker of disease initiation.
Reduced PD-1 expression on circulating CXCR5+ and CXCR5- FOXP3+ Treg cells marks type 1 diabetes initiation in children / A. Vecchione, J. Gerosa, R. Di Fonte, T. Jofra, C.M. Pia, V. Napoleone, E. Ippolito, G. Galvani, F. Ragogna, A. Stabilini, E. Bianconi, P. Grogan, C. Bonura, R. Bonfanti, G. Frontino, R. Nano, R. Melzi, M. De Pellegrin, A. Laurenzi, F. Meschi, G. Barera, A. Rigamonti, R. Indirli, E. Bosi, L. Piemonti, A. Aiuti, M. Battaglia, G. Fousteri. - In: CLINICAL IMMUNOLOGY. - ISSN 1521-6616. - 211(2020 Feb).
|Titolo:||Reduced PD-1 expression on circulating CXCR5+ and CXCR5- FOXP3+ Treg cells marks type 1 diabetes initiation in children|
|Parole Chiave:||AAb; AAb-negative; AAb-positive; CXCL13; PD-1; T1D; Tfh cells; Tfr cells|
|Settore Scientifico Disciplinare:||Settore MED/13 - Endocrinologia|
|Data di pubblicazione:||feb-2020|
|Data ahead of print / Data di stampa:||30-nov-2019|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.clim.2019.108319|
|Appare nelle tipologie:||01 - Articolo su periodico|