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AIR nasce in UNIMI nel 2006 con lo scopo di raccogliere, documentare e conservare le informazioni sulla produzione scientifica dell'Università degli Studi di Milano e costituisce di fatto l'Anagrafe della ricerca dell'Ateneo.
EnglishTransformation of simple indoles into (polycyclic) complex scaffolds has become the object of intensive studies in synthetic organic chemistry due to ubiquitous occurrence of indole core in the structure of relevant molecules In particular, catalytic-promoted manipulation of indoles have become an incomparable tool to increase indole structural complexity working under exceedingly mild conditions and in a regio- and stereo-controlled fashion. In this context we reported in the last years the synthesis of complex carbazole derivatives through gold-catalyzed (4+2) cycloaddition reactions of vinylindoles with different π-systems and the functionalization of structurally simple indoles with challenging metal-activated electrophiles. Taking into account these premises, this oral communication will deal with our recent achievements in the field of cycloaddition reactions involving vinylindoles as 4π systems and in gold-catalyzed cascade reactions on indole-based scaffolds. In particular we were able to extend cycloaddition of vinylindoles besides (4+2) processes to synthetize cyclohepta[b]indoles. Moreover, we explored the reactivity of 4H-furo[3,2-b]indoles with gold-activated π-systems to synthetize 2-spiro-3-oxindoles and 2-alkenyliden-indolin-3-ones selectively. Advantages of our methods as well as limitations and future perspectives will be discussed.
Catalytic transformations of indoles: recent achievements and new perspectives for the synthesis of complex indole derivatives / V. Pirovano, E. Rossi, E. Brambilla, G. Abbiati. ((Intervento presentato al 17. convegno Annual Meeting of the Pericyclic Reaction Centre tenutosi a Pavia nel 2019.
| Titolo: | Catalytic transformations of indoles: recent achievements and new perspectives for the synthesis of complex indole derivatives |
| Autori: | |
| Data di pubblicazione: | 28-nov-2019 |
| Parole Chiave: | Homogeneous catalysis; gold catalysis; indole |
| Settore Scientifico Disciplinare: | Settore CHIM/06 - Chimica Organica |
| Tipologia: | Conference Object |
| Citazione: | Catalytic transformations of indoles: recent achievements and new perspectives for the synthesis of complex indole derivatives / V. Pirovano, E. Rossi, E. Brambilla, G. Abbiati. ((Intervento presentato al 17. convegno Annual Meeting of the Pericyclic Reaction Centre tenutosi a Pavia nel 2019. |
| Appare nelle tipologie: | 14 - Intervento a convegno non pubblicato |
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|---|---|---|---|---|
| abstract-presentazione-Pirovano.pdf | Altro | Open Access Visualizza/Apri |
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