Neural tube defects (NTDs) result from failure of neural tube closure during embryogenesis. These severe birth defects of the central nervous system include anencephaly and spina bifida, and affect 0.5-2 per 1,000 pregnancies worldwide in humans. It has been demonstrated that acetylation plays a pivotal role during neural tube closure, as animal models for defective histone acetyltransferase proteins display NTDs. Acetylation represents an important component of the complex network of posttranslational regulatory interactions, suggesting a possible fundamental role during primary neurulation events. This study aimed to assess protein acetylation contribution to early patterning of the central nervous system both in human and murine specimens.

Dynamic acetylation profile during mammalian neurulation / V. Massa, L. Avagliano, P. Grazioli, S.C.P. De Castro, C. Parodi, D. Savery, P. Vergani, S. Cuttin, P. Doi, G. Bulfamante, A.J. Copp, N.D.E. Greene. - In: BIRTH DEFECTS RESEARCH. - ISSN 2472-1727. - (2019 Nov 23). [Epub ahead of print]

Dynamic acetylation profile during mammalian neurulation

V. Massa
Primo
;
L. Avagliano
Secondo
;
P. Grazioli;C. Parodi;G. Bulfamante;
2019

Abstract

Neural tube defects (NTDs) result from failure of neural tube closure during embryogenesis. These severe birth defects of the central nervous system include anencephaly and spina bifida, and affect 0.5-2 per 1,000 pregnancies worldwide in humans. It has been demonstrated that acetylation plays a pivotal role during neural tube closure, as animal models for defective histone acetyltransferase proteins display NTDs. Acetylation represents an important component of the complex network of posttranslational regulatory interactions, suggesting a possible fundamental role during primary neurulation events. This study aimed to assess protein acetylation contribution to early patterning of the central nervous system both in human and murine specimens.
Cited2; acetylation profile; neural tube defects; neurodevelopment; p53
Settore BIO/13 - Biologia Applicata
23-nov-2019
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/692367
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