Purpose: To contribute a global description of the spectrum of choroidal involvement in tubercular uveitis (TBU). Methods: Retrospective cohort study of TBU patients with choroidal involvement from 25 centers between January 2004 and December 2014. Medical records of patients with a minimum follow-up of 1 year were reviewed. Results: 245 patients were included. The phenotypic variations included serpiginous-like choroiditis (SLC) (46%), tuberculoma (13.5%), multifocal choroiditis (MFC) (9.4%), ampiginous choroiditis (9%), among others. 219 patients were treated with anti-tubercular therapy (ATT) (n = 219/245, 89.38%), 229 patients with steroids (n = 229/245, 93.47%) and 28 patients with immunosuppressive agents (n = 28/245, 11.42%). Treatment failure was noted in 38 patients (n = 38/245, 15.5%). Patients with SLC and ampiginous choroiditis appeared to have superior outcomes on survival analysis (p = 0.06). Conclusion: This study provides a comprehensive description of choroidal involvement in TBU. Patients with SLC and ampiginous choroiditis may have better clinical outcomes.
The Collaborative Ocular Tuberculosis Study (COTS)-1: A Multinational Description of the Spectrum of Choroidal Involvement in 245 Patients with Tubercular Uveitis / R. Agrawal, D.V. Gunasekeran, A. Agarwal, E. Carreno, K. Aggarwal, B. Gupta, D. Raje, S.I. Murthy, M. Westcott, S.P. Chee, P. Mccluskey, H.S. Ling, S. Teoh, L. Cimino, J. Biswas, S. Narain, M. Agarwal, P. Mahendradas, M. Khairallah, N. Jones, I. Tugal-Tutkun, K. Babu, S. Basu, R. Lee, H. Al-Dhibi, B. Bodaghi, A. Invernizzi, D.A. Goldstein, C.P. Herbort, T. Barisani-Asenbauer, J.J. Gonzalez-Lopez, S. Androudi, R. Bansal, B. Moharana, S. Mahajan, S. Esposti, A. Tasiopoulou, S. Nadarajah, M. Agarwal, S. Abraham, R. Vala, J. Lord, R. Singh, A. Sharma, K. Sharma, M. Zierhut, O.M. Kon, J. Kempen, E.T. Cunningham, A. Rousselot, Q.D. Nguyen, C. Pavesio, V. Gupta. - In: OCULAR IMMUNOLOGY AND INFLAMMATION. - ISSN 0927-3948. - (2018). [Epub ahead of print] [10.1080/09273948.2018.1489061]
The Collaborative Ocular Tuberculosis Study (COTS)-1: A Multinational Description of the Spectrum of Choroidal Involvement in 245 Patients with Tubercular Uveitis
A. Invernizzi;
2018
Abstract
Purpose: To contribute a global description of the spectrum of choroidal involvement in tubercular uveitis (TBU). Methods: Retrospective cohort study of TBU patients with choroidal involvement from 25 centers between January 2004 and December 2014. Medical records of patients with a minimum follow-up of 1 year were reviewed. Results: 245 patients were included. The phenotypic variations included serpiginous-like choroiditis (SLC) (46%), tuberculoma (13.5%), multifocal choroiditis (MFC) (9.4%), ampiginous choroiditis (9%), among others. 219 patients were treated with anti-tubercular therapy (ATT) (n = 219/245, 89.38%), 229 patients with steroids (n = 229/245, 93.47%) and 28 patients with immunosuppressive agents (n = 28/245, 11.42%). Treatment failure was noted in 38 patients (n = 38/245, 15.5%). Patients with SLC and ampiginous choroiditis appeared to have superior outcomes on survival analysis (p = 0.06). Conclusion: This study provides a comprehensive description of choroidal involvement in TBU. Patients with SLC and ampiginous choroiditis may have better clinical outcomes.File | Dimensione | Formato | |
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