A growing body of evidence implicates the human microbiome as a potentially influential player actively engaged in shaping the pathogenetic processes underlying the endotypes and phenotypes of chronic respiratory diseases, particularly of the airways. In this article, we specifically review current evidence on the characteristics of lung microbiome, and specifically the bacteriome, the modes of interaction between lung microbiota and host immune system, the role of the "lung-gut axis", and the functional effects thereof on asthma pathogenesis. We also attempt to explore the possibilities of therapeutic manipulation of the microbiome, aiming at the establishment of asthma prevention strategies and the optimization of asthma treatment.
Lung Microbiome in Asthma : Current Perspectives / K. Loverdos, G. Bellos, L. Kokolatou, I. Vasileiadis, E. Giamarellos, M. Pecchiari, N. Koulouris, A. Koutsoukou, N. Rovina. - In: JOURNAL OF CLINICAL MEDICINE. - ISSN 2077-0383. - 8:11(2019 Nov 14), pp. 1967.1-1967.32.
Lung Microbiome in Asthma : Current Perspectives
M. Pecchiari;
2019
Abstract
A growing body of evidence implicates the human microbiome as a potentially influential player actively engaged in shaping the pathogenetic processes underlying the endotypes and phenotypes of chronic respiratory diseases, particularly of the airways. In this article, we specifically review current evidence on the characteristics of lung microbiome, and specifically the bacteriome, the modes of interaction between lung microbiota and host immune system, the role of the "lung-gut axis", and the functional effects thereof on asthma pathogenesis. We also attempt to explore the possibilities of therapeutic manipulation of the microbiome, aiming at the establishment of asthma prevention strategies and the optimization of asthma treatment.File | Dimensione | Formato | |
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