We validated a symbolic approach to assess autonomic modulation from pulse interval (PI) and systolic arterial pressure (SAP) series obtained from an animal model of chronic heart failure (CHF). We studied three groups of rats: controls; CHF animals; CHF animals treated with spironolactone (CHF-SP), reducing sympathetic activity in CHF. Simulations confirmed that symbolic analysis captures modifications of cardiovascular regulation in the case of fast dynamics and negligible variance. While spectral indexes did not reveal any significant difference among groups, symbolic analysis pointed out that sympathetic modulation is reduced in CHF group and restored to basal values in CHF-SP one

Autonomic Cardiovascular Modulation / E. Tobaldini, N. Montano, S.G. Wei, Z.H. Zhang, J. Francis, R.M. Weiss, K.R. Casali, R.B. Felder, A. Porta. - In: IEEE ENGINEERING IN MEDICINE AND BIOLOGY MAGAZINE. - ISSN 0739-5175. - 28:6(2009), pp. 5335723.79-5335723.85.

Autonomic Cardiovascular Modulation

E. Tobaldini;N. Montano;A. Porta
2009

Abstract

We validated a symbolic approach to assess autonomic modulation from pulse interval (PI) and systolic arterial pressure (SAP) series obtained from an animal model of chronic heart failure (CHF). We studied three groups of rats: controls; CHF animals; CHF animals treated with spironolactone (CHF-SP), reducing sympathetic activity in CHF. Simulations confirmed that symbolic analysis captures modifications of cardiovascular regulation in the case of fast dynamics and negligible variance. While spectral indexes did not reveal any significant difference among groups, symbolic analysis pointed out that sympathetic modulation is reduced in CHF group and restored to basal values in CHF-SP one
Settore MED/09 - Medicina Interna
Settore ING-INF/06 - Bioingegneria Elettronica e Informatica
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/69218
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