Studies carried out in recent decades have revealed that the ability to self-assemble is a widespread property among biomolecules. Small nucleic acid moieties or very short peptides are able to generate intricate assemblies endowed with remarkable structural and spectroscopic properties. Herein, the structural/spectroscopic characterization of aggregates formed by nucleobases and peptide nucleic acid (PNA)-peptide conjugates are reported. At high concentration, all studied nucleobases form aggregates characterized by previously unreported fluorescence properties. The conjugation of these bases, as PNA derivatives, to the dipeptide Phe-Phe leads to the formation of novel hybrid assemblies, which are characterized by an amyloid-like association of the monomers. Although these compounds share the same basic cross-β motif, the nature and number of PNA units have an important impact on both the level of structural order and the intrinsic fluorescence of the self-assembled nanostructure.
Fluorescence and Morphology of Self-Assembled Nucleobases and Their Diphenylalanine Hybrid Aggregates / C. Avitabile, C. Diaferia, V. Roviello, D. Altamura, C. Giannini, L. Vitagliano, A. Accardo, A. Romanelli. - In: CHEMISTRY-A EUROPEAN JOURNAL. - ISSN 0947-6539. - 25:65(2019 Nov 22), pp. 14850-14857.
|Titolo:||Fluorescence and Morphology of Self-Assembled Nucleobases and Their Diphenylalanine Hybrid Aggregates|
ROMANELLI, ALESSANDRA (Ultimo) (Corresponding)
|Parole Chiave:||fluorescence; nucleobases; peptides; phenylalanine; self-assembly|
|Settore Scientifico Disciplinare:||Settore CHIM/03 - Chimica Generale e Inorganica|
|Data di pubblicazione:||22-nov-2019|
|Data ahead of print / Data di stampa:||ott-2019|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1002/chem.201902709|
|Appare nelle tipologie:||01 - Articolo su periodico|