This study compared the effects of fatigue on corticospinal responsiveness in the upper- and lower-limb muscles of the same participants. Seven healthy males performed a 2-min maximal voluntary isometric contraction of the elbow flexors or knee extensors on four separate days. Electromyographic responses were elicited by nerve stimulation (maximal M-wave) in all sessions and by transcranial magnetic stimulation (motor-evoked potential; silent period) and spinal tract stimulation (cervicomedullary or thoracic motor-evoked potentials; silent period) in one session each per limb. During sustained maximal voluntary contractions, motor-evoked potential area normalised to M-waves increased from baseline in biceps brachii (155 ± 55%) and rectus femoris (151 ± 44%) (both p ≤ 0.045). At the end of maximal voluntary contractions, spinal tract motor-evoked potential area normalised to M-waves was smaller than baseline in biceps brachii (74 ± 23%; p = 0.012) but not rectus femoris (108 ± 40%; p = 0.999). The ratio of motor-evoked potential to spinal tract-evoked potential areas increased dramatically from 90 to 115 s in biceps brachii (p = 0.001) but not in rectus femoris (p = 0.999). Silent period durations increased similarly in both muscles (p ≤ 0.008) after transcranial and spinal stimulation. Sustained maximal contractions elicit different neurophysiological adjustments in upper- and lower-limb muscles. Specifically, motoneuronal excitability was reduced in biceps brachii, but not in rectus femoris, and this reduction required greater compensatory adjustments from the motor cortex. Therefore, changes in cortical and spinal excitability during sustained maximal exercise are likely specific to the muscle performing the task.
Sustained Maximal Voluntary Contractions Elicit Different Neurophysiological Responses in Upper- and Lower-Limb Muscles in Men / J. Temesi, G. Vernillo, M. Martin, R.L. Krüger, C.J. Mcneil, G.Y. Millet. - In: NEUROSCIENCE. - ISSN 0306-4522. - 422(2019 Dec 01), pp. 88-98.
|Titolo:||Sustained Maximal Voluntary Contractions Elicit Different Neurophysiological Responses in Upper- and Lower-Limb Muscles in Men|
VERNILLO, GIANLUCA (Secondo)
|Parole Chiave:||Corticospinal excitability; Inhibition; Maximal voluntary contraction; Motoneuron; Spinal stimulation; Transcranial magnetic stimulation|
|Settore Scientifico Disciplinare:||Settore BIO/09 - Fisiologia|
Settore MED/26 - Neurologia
Settore M-EDF/02 - Metodi e Didattiche delle Attivita' Sportive
|Data di pubblicazione:||1-dic-2019|
|Data ahead of print / Data di stampa:||set-2019|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.neuroscience.2019.09.029|
|Appare nelle tipologie:||01 - Articolo su periodico|