Hepatitis E virus (HEV) is a worldwide public health concern, with an increase in human autochthonous cases in Europe. Although domestic pigs and wild boar (Sus scrofa) are the main reservoirs of HEV, the constant expansion of wild ruminants increases the potential for HEV transmission. We investigated HEV infection in chamois (Rupicapra rupicapra) and red deer (Cervus elaphus) in the Italian Alps using an enzyme-linked immunosorbent assay (ELISA). We detected HEV antibodies from 2013 to 2015 in both host species, with seroprevalences of 1.2% and 0.8% in chamois and red deer, respectively. All serum samples that were positive to HEV antibodies by ELISA were negative when tested by real-time reverse-transcriptase PCR to detect HEV RNA. The observed low seroprevalence of HEV suggested a sporadic circulation of HEV in the alpine environment, and it was consistent with the low seroprevalence observed in wild boar in the Alps. Our observations supported the role of chamois and red deer as spill-over hosts of HEV infections in the Italian Alps.

Low Serologic Prevalences Suggest Sporadic Infections of Hepatitis E Virus in Chamois (Rupicapra rupicapra) and Red Deer (Cervus elaphus) in the Italian Alps / T. Trogu, N. Ferrari, N. Formenti, V. Filipello, L. Pedrotti, R. Viganò, P. Lanfranchi, C. Luzzago. - In: JOURNAL OF WILDLIFE DISEASES. - ISSN 0090-3558. - 56:2(2020 Apr), pp. 443-446. [10.7589/2019-02-036]

Low Serologic Prevalences Suggest Sporadic Infections of Hepatitis E Virus in Chamois (Rupicapra rupicapra) and Red Deer (Cervus elaphus) in the Italian Alps

Trogu, Tiziana;Ferrari, Nicola;Formenti, Nicoletta;FILIPELLO, VIRGINIA;Lanfranchi, Paolo;Luzzago, Camilla
2020-04

Abstract

Hepatitis E virus (HEV) is a worldwide public health concern, with an increase in human autochthonous cases in Europe. Although domestic pigs and wild boar (Sus scrofa) are the main reservoirs of HEV, the constant expansion of wild ruminants increases the potential for HEV transmission. We investigated HEV infection in chamois (Rupicapra rupicapra) and red deer (Cervus elaphus) in the Italian Alps using an enzyme-linked immunosorbent assay (ELISA). We detected HEV antibodies from 2013 to 2015 in both host species, with seroprevalences of 1.2% and 0.8% in chamois and red deer, respectively. All serum samples that were positive to HEV antibodies by ELISA were negative when tested by real-time reverse-transcriptase PCR to detect HEV RNA. The observed low seroprevalence of HEV suggested a sporadic circulation of HEV in the alpine environment, and it was consistent with the low seroprevalence observed in wild boar in the Alps. Our observations supported the role of chamois and red deer as spill-over hosts of HEV infections in the Italian Alps.
Chamois; Italy; hepatitis E virus; red deer; seroprevalence
Settore VET/05 - Malattie Infettive degli Animali Domestici
Settore VET/06 - Parassitologia e Malattie Parassitarie degli Animali
28-ott-2019
JOURNAL OF WILDLIFE DISEASES
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/686960
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