BACKGROUND-AIMS: The SOLE study was conducted on a large cohort of Italian patients with moderate-severe Crohn's disease (CD) to assess epidemiological and disease characteristics and their correlation with disease-related worries, treatment satisfaction and adherence, workability. METHODS: The following tools were used over 12 months to assess: Results were correlated with demographic and clinical variables with linear regression models. RESULTS: 552 patients with active CD (51% men) were recruited. Higher worries were having an ostomy bag and undergoing surgery. Variables associated with a higher RFIPC score included female sex, higher disease activity, lower treatment adherence (p < 0.001), previous surgical treatments (p = 0.003). 60% of patients claimed difficulties with activities of daily living. Lower VAS scores were reported by patients with disease duration >6years; treatment satisfaction/adherence was higher with anti-TNF-α treatment. Decreased hospitalizations during follow-up and improved workability/daily activities occurred with adalimumab, infliximab, azathioprine (p < 0.001). CONCLUSION: Worries included having an ostomy bag, undergoing surgery, developing cancer: conditions significantly associated with worsened disease activity and low treatment adherence. Higher treatment adherence scores/greater workability improvements were observed in patients treated with anti-TNF-α agents.
Epidemiological features and disease-related concerns of a large cohort of Italian patients with active Crohn's disease / A. Armuzzi, G. Riegler, F. Furfaro, M. Baldoni, F. Costa, M. Fortuna, G. Iaquinto, P. Paese, C. Papi, F. Bossa, G.E. Tontini, S. Di Fino, G. Gualberti, R. Merolla, F. Rizzello. - In: DIGESTIVE AND LIVER DISEASE. - ISSN 1590-8658. - 51:6(2019), pp. 804-811.
|Titolo:||Epidemiological features and disease-related concerns of a large cohort of Italian patients with active Crohn's disease|
|Parole Chiave:||Crohn's disease; Patient's concerns; Quality of life; Treatment adherence and satisfaction|
|Settore Scientifico Disciplinare:||Settore MED/12 - Gastroenterologia|
|Data di pubblicazione:||2019|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.dld.2018.12.019|
|Appare nelle tipologie:||01 - Articolo su periodico|