Alcoholic liver disease and nonalcoholic liver disease represent a leading cause of liver disease and share similar pathogenic mechanisms among which activation of the immune system plays a key role. The main events consist in (a) activation of Kupffer cells via TLR-4 by LPS and fatty acids (b) complement activation (c) increased release of proinflammatory mediators (d) alteration in NK and NKT cell number/activity (e) activation of the adaptive immune system. At the same time, activation of intracellular pro-inflammatory pathways by cytokines and bacterial products, inhibit insulin signaling favoring lipogenesis, metabolic alterations, and cell damage
The immunopathogenesis of alcoholic and nonalcoholic steatohepatitis : two triggers for one disease? / L.V.C. Valenti, A.L. Fracanzani, S.R. Fargion. - In: SEMINARS IN IMMUNOPATHOLOGY. - ISSN 1863-2297. - 31:3(2009 Sep), pp. 359-369. [10.1007/s00281-009-0152-9]
The immunopathogenesis of alcoholic and nonalcoholic steatohepatitis : two triggers for one disease?
L.V.C. ValentiPrimo
;A.L. FracanzaniSecondo
;S.R. FargionUltimo
2009
Abstract
Alcoholic liver disease and nonalcoholic liver disease represent a leading cause of liver disease and share similar pathogenic mechanisms among which activation of the immune system plays a key role. The main events consist in (a) activation of Kupffer cells via TLR-4 by LPS and fatty acids (b) complement activation (c) increased release of proinflammatory mediators (d) alteration in NK and NKT cell number/activity (e) activation of the adaptive immune system. At the same time, activation of intracellular pro-inflammatory pathways by cytokines and bacterial products, inhibit insulin signaling favoring lipogenesis, metabolic alterations, and cell damageFile | Dimensione | Formato | |
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