Introduction Violence against women is a relevant heaklth and sociual problem, frequently associated with post traumatic stress diorder (PTSD), with negative repercussions on the overall quality of life. The projeect aim is to evaluate the psychological evolution in parallel with the epigenetic signature in battered women during their psychotherapy. Materials and methods Psychological therapy evaluation will be held by analysing a cohort of 200 women who experienced violence and 400 matched controls, followed for 18 months with medical and psychological appointments. Abbreviated PCL-C Posttraumatic checklist 6-item Civilian Version and CESD-R Scale for the presence of depressive symptoms will be administrated. A panel of CpG islands regulating, by methilation, genes involved in the PTSD response will be studied using Mass Array Spectrometry. Results In the first 6 months of multi-centric study, 42 women were enrolled as cases, selected by severity and continuity of violence criteria, and 25 as controls. In cases the prevalence of PTSD (score > 14) was 67.5% (EC 95.0%: 53.0% -- 82.0%) compared to 12.0% (EC 95.0%: - 0.7% -24.7%) among controls. Among the first 8 patients that completed first 6 months of follow-up 71.4% (EC 95.0%: 38.0% - 100.0%) showed an amelioration or remained stable as to PTSD score. Conclusions Great contribution to personalised and precision medicine will be given by the epigenetic study in association with the relevant questionnaire. By knowing the mechanisms responsible for resilience, we can derive clues about the best treatment for PTSD and the best public policy.

Women victims of intimate partner violence: psychological aspects and future epigenetics perspectives / A. Kustermann, A. Piccinini, P. Bailo, M. Miozzo, L. Micci, G. Barbara, E. Battaglioli, C. Farè, L. Cirella, A. Pitidis, P. Cremonesi, P. Schinco, T. Emanuele, D. Morero, S. Gaudi. ((Intervento presentato al convegno European Human Genetics Conference tenutosi a Milano nel 2018.

Women victims of intimate partner violence: psychological aspects and future epigenetics perspectives

A. Piccinini;P. Bailo;M. Miozzo;G. Barbara;E. Battaglioli;
2018

Abstract

Introduction Violence against women is a relevant heaklth and sociual problem, frequently associated with post traumatic stress diorder (PTSD), with negative repercussions on the overall quality of life. The projeect aim is to evaluate the psychological evolution in parallel with the epigenetic signature in battered women during their psychotherapy. Materials and methods Psychological therapy evaluation will be held by analysing a cohort of 200 women who experienced violence and 400 matched controls, followed for 18 months with medical and psychological appointments. Abbreviated PCL-C Posttraumatic checklist 6-item Civilian Version and CESD-R Scale for the presence of depressive symptoms will be administrated. A panel of CpG islands regulating, by methilation, genes involved in the PTSD response will be studied using Mass Array Spectrometry. Results In the first 6 months of multi-centric study, 42 women were enrolled as cases, selected by severity and continuity of violence criteria, and 25 as controls. In cases the prevalence of PTSD (score > 14) was 67.5% (EC 95.0%: 53.0% -- 82.0%) compared to 12.0% (EC 95.0%: - 0.7% -24.7%) among controls. Among the first 8 patients that completed first 6 months of follow-up 71.4% (EC 95.0%: 38.0% - 100.0%) showed an amelioration or remained stable as to PTSD score. Conclusions Great contribution to personalised and precision medicine will be given by the epigenetic study in association with the relevant questionnaire. By knowing the mechanisms responsible for resilience, we can derive clues about the best treatment for PTSD and the best public policy.
16-giu-2018
Settore MED/43 - Medicina Legale
Women victims of intimate partner violence: psychological aspects and future epigenetics perspectives / A. Kustermann, A. Piccinini, P. Bailo, M. Miozzo, L. Micci, G. Barbara, E. Battaglioli, C. Farè, L. Cirella, A. Pitidis, P. Cremonesi, P. Schinco, T. Emanuele, D. Morero, S. Gaudi. ((Intervento presentato al convegno European Human Genetics Conference tenutosi a Milano nel 2018.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/683707
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