Non-transferrin-bound iron (NTBI) was evaluated as an index of iron overload in a cross-sectional randomised study in 74 non-transfused patients with thalassaemia intermedia (TI). Mean NTBI (2.92 ± 3.43 μmol/l), serum ferritin (1023 ± 780 ng/ml) and liver iron concentration (LIC; 9.0 ± 7.4 mg Fe/g dry weight) were increased above reference-range levels. Significant positive correlations occurred between mean NTBI and LIC (Pearson correlation 0.36; P = 0.002) and serum ferritin (Pearson correlation 0.421; P < 0.0001); with higher levels observed in splenectomised patients. NTBI assessment has potential as a simple reliable approach to determining iron status in TI.
|Titolo:||Levels of non-transferrin-bound iron as an index of iron overload in patients with thalassaemia intermedia|
CAPPELLINI, MARIA DOMENICA (Ultimo)
|Parole Chiave:||Iron overload; Non-transferrin-bound iron; Thalassaemia intermedia|
|Settore Scientifico Disciplinare:||Settore MED/09 - Medicina Interna|
|Data di pubblicazione:||set-2009|
|Digital Object Identifier (DOI):||10.1111/j.1365-2141.2009.07810.x|
|Appare nelle tipologie:||01 - Articolo su periodico|