Anomalie della sostanza bianca nella sclerosi Tuberosa: un criterio minore sottodiagnosticato?

Neuroimaging studies of tuberous sclerosis complex (TSC) have previously focused mainly on tubers or subependymal nodules. Subtle pathological changes as white matter abnormalities in the structure of the brain have not been focused. We utilized MRI techniques for reliable study of brain structure to reach an accurate computation of brain abnormalities in patients with TSC. We also found significant alteration of white matter as stripes and candle guttering excrescences of groups of atypical cells perpendicular to the ventricular wall 21 of 27 TSC affected patients. Neuropathological changes of white matter associated with TSC may be more extensive than prior suspected and it could be a underdiagnoised "minor" criteria.