Previous works linked low sodium concentration with mortality risk in cancer. We aimed at weighing the prognostic impact of hyponatremia in all consecutive patients with metastatic solid tumors admitted in a two-years period at our medical oncology department. Patients were included in two cohorts based on serum sodium concentration on admission. A total of 1025 patients were included, of whom 279 (27.2%) were found to be hyponatremic. The highest prevalence of hyponatremia was observed in biliary tract (51%), prostate (45%) and small-cell lung cancer (38.9%). With a median follow-up of 26.9 months, median OS was 2 months and 13.2 months for the hyponatremia versus control cohort, respectively (HR, 2.65; P < 0.001). In the multivariable model, hyponatremia was independently associated with poorer OS (HR, 1.66; P < 0.001). According to the multivariable model, a nomogram system was developed and validated in an external set of patients. We weighed over time the influence of hyponatremia on survival of patients with metastatic solid tumors and pointed out the possibility to exploit serum sodium assessment to design integrated prognostic tools. Our study also highlights the need for a deeper characterization of the biological role of extracellular sodium levels in tumor development and progression.
Weighing the prognostic role of hyponatremia in hospitalized patients with metastatic solid tumors: the HYPNOSIS study / G. Fucà, L. Mariani, S. Lo Vullo, G. Galli, R. Berardi, M. Di Nicola, C. Vernieri, D. Morelli, K. Dotti, I. Fiordoliva, S. Rinaldi, C. Gavazzi, F. Pietrantonio, M. Platania, F. de Braud. - In: SCIENTIFIC REPORTS. - ISSN 2045-2322. - 9:1(2019 Dec 01).
|Titolo:||Weighing the prognostic role of hyponatremia in hospitalized patients with metastatic solid tumors: the HYPNOSIS study|
FUCA', GIOVANNI (Primo) (Corresponding)
DE BRAUD, FILIPPO GUGLIELMO MARIA (Ultimo)
|Settore Scientifico Disciplinare:||Settore MED/06 - Oncologia Medica|
|Data di pubblicazione:||1-dic-2019|
|Data ahead of print / Data di stampa:||10-set-2019|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1038/s41598-019-49601-3|
|Appare nelle tipologie:||01 - Articolo su periodico|