The centrality of the mitochondrion in the evolution and control of the cell are now supported by many experimental studies. Not only with regard to the energy metabolism but also and especially with regard to the other functions indispensable for the cell such as apoptosis and the control of innate immunity through different complex cell signaling pathways. All this makes them one of the main targets during infections supported by pathogenic microorganisms. The interaction and control of these organelles by pathogens results, from the latest experimental evidence, of fundamental importance in the fate of the host cell and in the progression of infectious diseases.
Role of Mitochondria in Host-Pathogen Interaction / A. Soggiu, P. Roncada, L. Bonizzi, C. Piras (ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY). - In: Mitochondria in Health and in Sickness / [a cura di] A. Urbani, M. Babu. - Prima edizione. - [s.l] : Springer Nature, 2019 Aug. - ISBN 9789811383663. - pp. 45-57 [10.1007/978-981-13-8367-0_3]
Role of Mitochondria in Host-Pathogen Interaction
A. Soggiu
Primo
Writing – Original Draft Preparation
;L. Bonizzi;
2019
Abstract
The centrality of the mitochondrion in the evolution and control of the cell are now supported by many experimental studies. Not only with regard to the energy metabolism but also and especially with regard to the other functions indispensable for the cell such as apoptosis and the control of innate immunity through different complex cell signaling pathways. All this makes them one of the main targets during infections supported by pathogenic microorganisms. The interaction and control of these organelles by pathogens results, from the latest experimental evidence, of fundamental importance in the fate of the host cell and in the progression of infectious diseases.
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