BACKGROUND: Research has consistently shown that language abilities represent a core dimension of psychosis; however, to date, very little is known about syntactic comprehension performance in the early stages of psychosis. This study aims to compare the linguistic abilities involved in syntactic comprehension in a large group of First Episode Psychosis (FEP) patients and healthy controls (HCs). METHODS: A multiple choice test of comprehension of syntax was administered to 218 FEP patients (166 non-affective FEP patients [FEP-NA] and 52 affective FEP patients [FEP-A]) and 106 HCs. All participants were asked to match a sentence they listen with one out of four vignettes on a pc screen. Only one vignette represents the stimulus target, while the others are grammatical or non-grammatical (visual) distractors. Both grammatical and non-grammatical errors and performance in different syntactic constructions were considered. RESULTS: FEP committed greater number of errors in the majority of TCGB language domains compared to HCs. Moreover, FEP-NA patients committed significantly more non-grammatical (z = -3.2, p = 0.007), locative (z = -4.7, p < 0.001), passive-negative (z = -3.2, p = 0.02), and relative (z = -4.6, p < 0.001) errors compared to HCs as well as more passive-affirmative errors compared to both HCs (z = -4.3, p < 0.001) and FEP-A (z = 3.1, p = 0.04). Finally, we also found that both FEP-NA and FEP-A committed more grammatical (FEP-NA: z = -9.2, p < 0.001 and FEP-A: z = -4.4, p < 0.001), total (FEP-NA: z = -8.2, p < 0.001 and FEP-A: z = 3.9, p = 0.002), and active-negative (FEP-NA: z = -5.8, p < 0.001 and FEP-A: z = -3.5, p = 0.01) errors compared to HCs. CONCLUSIONS: This study shows that the access to syntactic structures is already impaired in FEP patients, especially in those with FEP-NA, ultimately suggesting that language impairments represent a core and inner feature of psychosis even at early stages.
Altered syntactic abilities in first episode patients : an inner phenomenon characterizing psychosis / G. Delvecchio, E. Caletti, C. Perlini, F.M. Siri, A. Andreella, L. Finos, M. Bellani, F. Fabbro, A. Lasalvia, C. Bonetto, D. Cristofalo, P. Scocco, A. D'Agostino, S. Torresani, M. Imbesi, F. Bellini, A. Veronese, C. Bressi, M. Ruggeri, P. Brambilla. - In: EUROPEAN PSYCHIATRY. - ISSN 0924-9338. - 61(2019 Sep), pp. 119-126.
|Titolo:||Altered syntactic abilities in first episode patients : an inner phenomenon characterizing psychosis|
BRAMBILLA, PAOLO (Corresponding)
|Parole Chiave:||Affective psychosis; First episode psychosis; Grammar; Language; Non-affective psychosis; Syntax|
|Settore Scientifico Disciplinare:||Settore MED/25 - Psichiatria|
|Data di pubblicazione:||set-2019|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.eurpsy.2019.08.001|
|Appare nelle tipologie:||01 - Articolo su periodico|