Native hypovitaminosis D (n-hVITD) is frequently found from the early stages of chronic kidney disease (CKD) and its prevalence increases with CKD progression. Even if the implications of n-hVITD in chronic kidney disease-mineral bone disorder (CKD-MBD) have been extensively characterized in the literature, there is a lot of debate nowadays about the so called "unconventional effects" of native vitamin D (25(OH)VitD) supplementation in CKD patients. In this review, highlights of the dimension of the problem of n-hVITD in CKD stages 2-5 ND patients will be presented. In addition, it will focus on the "unconventional effects" of 25(OH)VitD supplementation, the clinical impact of n-hVITD and the most significant interventional studies regarding 25(OH)VitD supplementation in CKD stages 2-5 ND.

Native Hypovitaminosis D in CKD Patients : From Experimental Evidence to Clinical Practice / C. Alfieri, O. Ruzhytska, S. Vettoretti, L. Caldiroli, M. Cozzolino, P. Messa. - In: NUTRIENTS. - ISSN 2072-6643. - 11:8(2019 Aug 15), pp. 1918.1-1918.14. [10.3390/nu11081918]

Native Hypovitaminosis D in CKD Patients : From Experimental Evidence to Clinical Practice

C. Alfieri
Primo
;
L. Caldiroli;M. Cozzolino
Penultimo
;
P. Messa
Ultimo
2019

Abstract

Native hypovitaminosis D (n-hVITD) is frequently found from the early stages of chronic kidney disease (CKD) and its prevalence increases with CKD progression. Even if the implications of n-hVITD in chronic kidney disease-mineral bone disorder (CKD-MBD) have been extensively characterized in the literature, there is a lot of debate nowadays about the so called "unconventional effects" of native vitamin D (25(OH)VitD) supplementation in CKD patients. In this review, highlights of the dimension of the problem of n-hVITD in CKD stages 2-5 ND patients will be presented. In addition, it will focus on the "unconventional effects" of 25(OH)VitD supplementation, the clinical impact of n-hVITD and the most significant interventional studies regarding 25(OH)VitD supplementation in CKD stages 2-5 ND.
CKD; cardiovascular risk; mineral metabolism; vitamin D; vitamin D supplementation
Settore MED/14 - Nefrologia
15-ago-2019
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/672079
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