Aim: To evaluate the suitability of bioactive glass (BAG)-S53P4 as a bone-graft extender for large bony defect filling in bone and joint infection. Materials & methods: Antimicrobial activity of BAG-S53P4 against clinically relevant strains isolated from bone and joint infections was evaluated by means of time-kill curves in presence of bone graft. Furthermore, the susceptibility to BAG of strains resistant to vancomycin and gentamicin was assessed. Results: Though attenuated, BAG maintains a good in vitro antimicrobial activity in presence of human body fluids and tissues contained in bone graft, with the exception of Enterococcus faecalis. Conclusion: BAG-S53P4 is a suitable bone substitute that can be used as an extender with autologous bone graft to promote better fusion and healing.
BAG-S53P4 as bone graft extender and antimicrobial activity against gentamicin- and vancomycin-resistant bacteria / M. Bortolin, C.L. Romano, A. Bidossi, E. De Vecchi, R. Mattina, L. Drago. - In: FUTURE MICROBIOLOGY. - ISSN 1746-0913. - 13:5(2018), pp. 525-533.
|Titolo:||BAG-S53P4 as bone graft extender and antimicrobial activity against gentamicin- and vancomycin-resistant bacteria|
DRAGO, LORENZO (Corresponding)
|Parole Chiave:||antimicrobial activity; BAG-S53P4; bioactive glass; bone and joint infections; bone graft; Enterobacteriaceae; gentamicin; MRSA; MRSE; vancomycin; Anti-Infective Agents; Autografts; Bone Substitutes; Bone and Bones; Dose-Response Relationship, Drug; Drug Resistance, Multiple, Bacterial; Gentamicins; Glass; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Hydrogen-Ion Concentration; Microbial Sensitivity Tests; Vancomycin|
|Settore Scientifico Disciplinare:||Settore MED/07 - Microbiologia e Microbiologia Clinica|
|Data di pubblicazione:||2018|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.2217/fmb-2016-0171|
|Appare nelle tipologie:||01 - Articolo su periodico|