Blood to skin recirculation could play a role in the pathogenesis of psoriasis. To investigate this possibility we dissected the phenotype of circulating T cells in psoriasis patients, calculated the correlation the clinical parameters of the disease and performed a parallel bioinformatics analysis of gene expression data in psoriatic skin. We found that circulating CCR6(+) CD4(+) TEM and TEFF cells significantly correlated with systemic inflammation. Conversely, the percentage of CXCR3(+) CD4(+) TEM cells negatively correlated with the severity of the cutaneous disease. Importantly CLA(+) CD4(+) TCM cells expressing CCR6(+) or CCR4(+)CXCR3(+) negatively correlated with psoriasis severity suggesting recruitment to the skin compartment. This assumption was reinforced by gene expression data showing marked increase of CCR7 and CLA-encoding gene SELPLG expression in psoriatic skin and strong association of their expression. The data enlightens a role for CD4(+) T cells trafficking between blood and skin in cutaneous and systemic manifestations of psoriasis.
Blood to skin recirculation of CD4(+) memory T cells associates with cutaneous and systemic manifestations of psoriatic disease / M. Diani, M. Galasso, C. Cozzi, F. Sgambelluri, A. Altomare, C. Cigni, E. Frigerio, L. Drago, S. Volinia, F. Granucci, G. Altomare, E. Reali. - In: CLINICAL IMMUNOLOGY. - ISSN 1521-6616. - 180(2017 Jul), pp. 84-94.
|Titolo:||Blood to skin recirculation of CD4(+) memory T cells associates with cutaneous and systemic manifestations of psoriatic disease|
|Parole Chiave:||Adult; Antigens, Differentiation, T-Lymphocyte; C-Reactive Protein; CD4-Positive T-Lymphocytes; Cytokines; Female; Humans; Immunologic Memory; Male; Membrane Glycoproteins; Middle Aged; Psoriasis; Receptors, Chemokine; Severity of Illness Index; Skin; Young Adult|
|Settore Scientifico Disciplinare:||Settore MED/07 - Microbiologia e Microbiologia Clinica|
|Data di pubblicazione:||lug-2017|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.clim.2017.04.001|
|Appare nelle tipologie:||01 - Articolo su periodico|