Urothelial cell carcinoma in situ (CIS) of the bladder is a superficially diffusive and highly discohesive disease. The authors analyzed the expression of some adhesion molecules (e-cadherin and Ep-CAM) and MUC1 in 32 unifocal and multifocal bladder urothelial cell CIS in an attempt to clarify this discohesion. E-cadherin was strongly expressed, in more than 75% of the cases. The presence of methylation of the CDH1 e-cadherin promoter gene was also investigated, but methylation was found in only one case. Ep-CAM was present in all the cases with a heterogeneous staining pattern. Similarly, MUC1/episialin was variously present in 94% of the cases without a polarized staining pattern and was expressed more strongly in cases with multifocal disease. Because loss of MUC1 polarization leads to interference with cell-cell adhesion mechanisms mediated by cadherins, these findings help explain why bladder urothelial cell CIS often shows a discohesive morphology and multifocality despite a strongly expressed adhesion molecule profile. Finally, Ep-CAM expression might provide some support for future target therapy trials.
Cell discohesion and multifocality of carcinoma in situ of the bladder: new insight from the adhesion molecule profile (e-cadherin, Ep-CAM, and MUC1) / C. Patriarca, P. Colombo, A. Pio Taronna, J. Wesseling, G. Franchi, F. Guddo, R. Naspro, R. M. Macchi, P. Giunta, M. Di Pasquale, M. Parente, C. Arizzi, M. Roncalli, B. Campo. - In: INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY. - ISSN 1066-8969. - 17:2(2009), pp. 99-106.
|Titolo:||Cell discohesion and multifocality of carcinoma in situ of the bladder: new insight from the adhesion molecule profile (e-cadherin, Ep-CAM, and MUC1)|
RONCALLI, MASSIMO (Penultimo)
|Parole Chiave:||Bladder; Carcinoma in situ (CIS); Discohesion; E-cadherin; MUC1; Urothelial cell carcinoma|
|Settore Scientifico Disciplinare:||Settore MED/08 - Anatomia Patologica|
|Data di pubblicazione:||2009|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1177/1066896908326918|
|Appare nelle tipologie:||01 - Articolo su periodico|