Natural Killer (NK)cells are innate lymphocytes able to mediate immune-surveillance and clearance of viral infected and tumor-transformed cells. Growing experimental and clinical evidence highlighted a dual role of NK cells either in the control of cancer development/progression or in promoting the onset of immune-suppressant tumor microenvironments. Indeed, several mechanisms of NK cell-mediated tumor escape have been described and these includes cancer-induced aberrant expression of activating and inhibitory receptors (i.e. NK cell immune checkpoints), impairments of NK cell migration to tumor sites and altered NK cell effector-functions. These phenomena highly contribute to tumor progression and metastasis formation. In this review, we discuss the latest insights on those NK cell receptors and related molecules that are currently being implemented in clinics either as possible prognostic factors or therapeutic targets to unleash NK cell anti-tumor effector-functions in vivo. Moreover, we address here the major recent advances in regard to the genetic modification and ex vivo expansion of anti-tumor specific NK cells used in innovative adoptive cellular transfer approaches.
NK cells to cure cancer / C. Di Vito, J. Mikulak, E. Zaghi, S. Pesce, E. Marcenaro, D. Mavilio. - In: SEMINARS IN IMMUNOLOGY. - ISSN 1044-5323. - 41(2019 Feb). [Epub ahead of print]
Titolo: | NK cells to cure cancer |
Autori: | MAVILIO, DOMENICO (Corresponding) |
Parole Chiave: | Adoptive NK cell therapy; Cancer therapy; ILC1; Immune checkpoints; Immune-surveillance; NK cell receptors; NK cells |
Settore Scientifico Disciplinare: | Settore MED/46 - Scienze Tecniche di Medicina di Laboratorio Settore MED/04 - Patologia Generale Settore MED/06 - Oncologia Medica Settore MED/15 - Malattie del Sangue |
Data di pubblicazione: | feb-2019 |
Rivista: | |
Tipologia: | Article (author) |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.smim.2019.03.004 |
Appare nelle tipologie: | 01 - Articolo su periodico |
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