Ascaridia galli, an intestinal nematode that effects hens and other domestic and wild birds, causes economic losses in avian exploitations. The present work shows that A. galli stimulates a strongly antibody response as well as an intense inflammatory reaction, in the intestinal mucous of experimentally infected Lohmann Brown laying hens. IgG antibodies against soluble extracts of A. galli embrionated eggs and adult worms, were detected in both blood and yolks egges from infected hens during a period of 105 days after the infection. This indicates that hens transger to their offspring a part of the IgG antibodies produced when they become infected. The entigens responsible for the stimulation of specific IgG were molecules of 30-34, 44-54 and 58-90 KDa, while in the yolk eggs of infected hens a reactivity directed against antigens of molecular weight lower than 50 KDa was detected. Histology revealed traumatic lesions with leukocyte infiltration, and inflammation of the intestinal wall of the infected hens after 105 days of initial infection. The possible influence of the immune and inflammatory response onthe population dynamics of the parasite is discussed.
|Titolo:||Antibody and inflammatory responses in laying hens with experimental primary infections of Ascaridia galli|
GANDOLFI, BARBARA (Secondo)
|Parole Chiave:||Antibody; Ascaridia galli; Blood; Inflammatory response; Intestinal mucous; Yolk|
|Settore Scientifico Disciplinare:||Settore AGR/17 - Zootecnica Generale e Miglioramento Genetico|
|Data di pubblicazione:||6-apr-2009|
|Digital Object Identifier (DOI):||10.1016/j.vetpar.2008.12.011|
|Appare nelle tipologie:||01 - Articolo su periodico|