The addition of Ru3(CO)12, dimethylcarbonate, or both to the reaction mixture improves the selectivity of the palladium-phenanthroline catalyzed reaction of nitroarenes, arylalkynes and CO to give 3-arylindoles. When 4-fluorophenylacetylene and nitrobenzene are used as substrates, the indole skeleton of Fluvastatin and other pharmaceutically active compounds is obtained in one step.
Synthesis of indoles by intermolecular cyclization of unfunctionalized nitroarenes and alkynes : one step synthesis of the skeleton of fluvastatin / F. Ragaini, F. Ventriglia, M. Hagar, S. Fantauzzi, S. Cenini. - In: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. - ISSN 1434-193X. - :13(2009), pp. 2185-2189. [10.1002/ejoc.200801274]
Synthesis of indoles by intermolecular cyclization of unfunctionalized nitroarenes and alkynes : one step synthesis of the skeleton of fluvastatin
F. RagainiPrimo
;S. FantauzziPenultimo
;S. CeniniUltimo
2009
Abstract
The addition of Ru3(CO)12, dimethylcarbonate, or both to the reaction mixture improves the selectivity of the palladium-phenanthroline catalyzed reaction of nitroarenes, arylalkynes and CO to give 3-arylindoles. When 4-fluorophenylacetylene and nitrobenzene are used as substrates, the indole skeleton of Fluvastatin and other pharmaceutically active compounds is obtained in one step.
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