Tumor necrosis factor (TNF) inhibitors are associated with greater improvements in the symptoms and signs of rheumatoid arthritis (RA) and, more importantly, a lower risk of joint damage. TNF is an important mediator of the alterations in neuroendocrine axes characterizing RA. Long-term therapy with anti-TNF agents sensitizes the pituitary gland and improves adrenal androgen secretion, thus stimulating an alternative form of anti-inflammatory action.
Anti-TNF therapy restores the hypothalamic-pituitary-adrenal axis : Annals of the New York Academy of Sciences / F. Atzeni, R.H. Straub, M. Cutolo, P. Sarzi-Puttini. - In: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. - ISSN 0077-8923. - 1193:1(2010 Apr), pp. 179-181. ((Intervento presentato al 4. convegno International Conference on Neuroendocrine Immunology in Rheumatic Diseases Location tenutosi a Genova nel 2009 [10.1111/j.1749-6632.2009.05366.x].
Anti-TNF therapy restores the hypothalamic-pituitary-adrenal axis : Annals of the New York Academy of Sciences
P. Sarzi-Puttini
2010
Abstract
Tumor necrosis factor (TNF) inhibitors are associated with greater improvements in the symptoms and signs of rheumatoid arthritis (RA) and, more importantly, a lower risk of joint damage. TNF is an important mediator of the alterations in neuroendocrine axes characterizing RA. Long-term therapy with anti-TNF agents sensitizes the pituitary gland and improves adrenal androgen secretion, thus stimulating an alternative form of anti-inflammatory action.
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