Background: To understand if relapse, following antimicrobial treatment was due to re-infection or to recrudescence. Methods: Fifty patients with dyspepsia were studied prospectively. They were followed up by endoscopy and biopsy of antral mucosa before and after treatment with anti-microbial therapy. Gel isoelectrofocusing was used to characterize protein profile of Hp. Results: At baseline 40 patients were affected by chronic gastritis associated with Hp. At the end of treatment 75% patients given omeprazole, amoxicillin and clarithromycin were Hp infected: 43% showed the same protein profile and 57% different. Conclusions: Our data suggest that the relapse is due to recrudescence or to reinfection.

Protein profile of Helicobacter pylori strains by isoelectrofocusing in patients affected by chronic gastritis / S.P. Paparo, G. Petrigni, F. Giovannelli, A. Cerroni, R. Caroselli, C. De Rosa. - In: EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES. - ISSN 2284-0729. - 7:6(2003), pp. 171-173.

Protein profile of Helicobacter pylori strains by isoelectrofocusing in patients affected by chronic gastritis

G. Petrigni
Secondo
;
2003

Abstract

Background: To understand if relapse, following antimicrobial treatment was due to re-infection or to recrudescence. Methods: Fifty patients with dyspepsia were studied prospectively. They were followed up by endoscopy and biopsy of antral mucosa before and after treatment with anti-microbial therapy. Gel isoelectrofocusing was used to characterize protein profile of Hp. Results: At baseline 40 patients were affected by chronic gastritis associated with Hp. At the end of treatment 75% patients given omeprazole, amoxicillin and clarithromycin were Hp infected: 43% showed the same protein profile and 57% different. Conclusions: Our data suggest that the relapse is due to recrudescence or to reinfection.
Settore MED/10 - Malattie dell'Apparato Respiratorio
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/66558
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