Autoantibodies to Ro(SS-A) may recognize two different polypeptides, of 52 kDa and 60 kDa, respectively. We used an ELISA with purified human recombinant antigens to conduct a detailed analysis of the specificities of anti-Ro(SS-A) antibodies from 170 patients with definite diagnoses (systemic lupus erythematosus [SLE], n = 55; primary Sjogren's syndrome [PSS], n = 39; systemic sclerosis, n= 9; rheumatoid arthritis [RA], n = 10) or undifferentiated connective tissue disease (UCTD, n = 57). Most of the patients with SLE or PSS had both anti-52 kDa and -60 antibodies; isolated anti-60 kDa antibodies were found in 13% of the SLE patients and in none of the PSS patients, whereas high titers of anti-52 kDa were more common in the PSS than in the SLE patients. In the UCTD patients, the anti-Ro(SS-A) profile showed no significant correlations with clinical features but was associated with the clinical outcome. Over the mean follow-up of five years, definite SLE developed in four of the five UCTD patients with isolated anti-60 kDa vs only one of the remaining 52 patients (P < 0.0001); progression to PSS was seen in seven of the 34 patients with both anti-52 kDa and anti-60 kDa vs none of the remaining 23 patients (P= 0.03); none of the 12 patients with isolated anti-52 kDa developed a definite connective tissue disease. Conclusion. Our study suggests that analysis of anti-Ro(SS-A) specificity may provide useful information far predicting the course of UCTD.
Anti-Ro(SS-A) 52 kDa and 60 kDa specificities in undifferentiated connective tissue disease / N. Belfiore, S. Rossi, F. Bobbio-Pallavicini, O. Epis, R. Caporali, C. Montecucco. - In: JOINT BONE SPINE. - ISSN 1297-319X. - 67:3(2000), pp. 183-187.
|Titolo:||Anti-Ro(SS-A) 52 kDa and 60 kDa specificities in undifferentiated connective tissue disease|
|Parole Chiave:||anti-Ro(SS-A) autoantibodies; undifferentiated connective tissue disease|
|Settore Scientifico Disciplinare:||Settore MED/16 - Reumatologia|
|Data di pubblicazione:||2000|
|Appare nelle tipologie:||01 - Articolo su periodico|