A quantitative immunoassay using a highly purified antigen from HeLa cells has allowed us to detect antibodies to SSB/La in 11/20 patients with primary Sjogren's syndrome (SS), 15/33 with SLE, and 11/35 with progressive systemic sclerosis (PSS). However, positive results were found in only 2/12 patients with idiopathic Raynaud's disease and 2/20 with rheumatoid arthritis, including 4 with secondary SS. Anti-SSB/La were associated with extraglandular manifestations in primary SS, and with a diffuse sclerodermic pattern in PSS. In SS, SLE and PSS, a positive anti-SSB/La test was strongly associated with nodal or spleen enlargement and with an increased level of γ-globulins. A direct association was also found with positive tests for rheumatoid factors, anti-SSA/Ro and anti-Scl 70. An inverse relationship was however found with anti-nRNP ± Sm and anticentromere antibodies. Our data suggest that anti-SSB/La antibodies can be regarded as a marker of B-lymphocyte activation in patients with either primary SS, SLE or PSS.
Anti-ssb/la Antibodies In Sjogrens Syndrome and Related Autoimmune-diseases - Results of A Quantitative Immunoassay Using A Highly Purified Antigen / C. Montecucco, M. Bestagno, A. Cerino, R. Caporali, R. Carnevale, M. Longhi, M.A. Pedrini, G. C. B.. - In: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. - ISSN 0392-856X. - 7:1(1989), pp. 5-11.
|Titolo:||Anti-ssb/la Antibodies In Sjogrens Syndrome and Related Autoimmune-diseases - Results of A Quantitative Immunoassay Using A Highly Purified Antigen|
|Settore Scientifico Disciplinare:||Settore MED/16 - Reumatologia|
|Data di pubblicazione:||1989|
|Appare nelle tipologie:||01 - Articolo su periodico|