Coronary artery disease is one of the leading causes of death worldwide. The stenotic coronary vessels are generally treated with coronary artery bypass grafts (CABGs), which can be either arterial (internal mammary artery, radial artery) or venous (saphenous vein). However, the different mechanical properties of the graft can influence the outcome of the procedure in terms of risk of restenosis and subsequent graft failure. In this paper, we perform a computational fluid–structure interaction (FSI) analysis of patient-specific multiple CABGs (Y-grafts) with the aim of better understanding the influence of the choice of bypass (arterial vs venous) on the risk of graft failure. Our results show that the use of a venous bypass results in a more disturbed flow field at the anastomosis and in higher stresses in the vessel wall with respect to the arterial one. This could explain the better long-term patency of the arterial bypasses experienced in the clinical practice.

A computational fluid–structure interaction analysis of coronary Y-grafts / B. Guerciotti, C. Vergara, S. Ippolito, A. Quarteroni, C. Antona, R. Scrofani. - In: MEDICAL ENGINEERING & PHYSICS. - ISSN 1350-4533. - 47(2017), pp. 117-127.

A computational fluid–structure interaction analysis of coronary Y-grafts

C. Vergara
;
C. Antona;
2017

Abstract

Coronary artery disease is one of the leading causes of death worldwide. The stenotic coronary vessels are generally treated with coronary artery bypass grafts (CABGs), which can be either arterial (internal mammary artery, radial artery) or venous (saphenous vein). However, the different mechanical properties of the graft can influence the outcome of the procedure in terms of risk of restenosis and subsequent graft failure. In this paper, we perform a computational fluid–structure interaction (FSI) analysis of patient-specific multiple CABGs (Y-grafts) with the aim of better understanding the influence of the choice of bypass (arterial vs venous) on the risk of graft failure. Our results show that the use of a venous bypass results in a more disturbed flow field at the anastomosis and in higher stresses in the vessel wall with respect to the arterial one. This could explain the better long-term patency of the arterial bypasses experienced in the clinical practice.
CABG; FSI; Intimal hyperplasia; Non-Newtonian rheology; Restenosis; Blood Flow Velocity; Computer Simulation; Coronary Artery Bypass; Coronary Stenosis; Coronary Vessels; Humans; Hydrodynamics; Patient-Specific Modeling; Treatment Outcome; Coronary Circulation; Models, Cardiovascular
Settore MED/23 - Chirurgia Cardiaca
Settore ING-IND/34 - Bioingegneria Industriale
2017
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/665321
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