Parkinson's disease (PD) is a neurodegenerative disorder whose aetiology remains unclear: degeneration involves several neurotransmission systems, resulting in a heterogeneous disease characterized by motor and non-motor symptoms. PD causes progressive disability that responds only to symptomatic therapies. Future advances include neuroprotective strategies for use in at-risk populations before the clinical onset of disease, hence the continuing need to identify reliable biomarkers that can facilitate the clinical diagnosis of PD. In this evaluative review, we summarize information on potential diagnostic biomarkers for use in the clinical and preclinical stages of PD.
Diagnostic biomarkers for Parkinson's disease at a glance : where are we? / I. Cova, A. Priori. - In: JOURNAL OF NEURAL TRANSMISSION. - ISSN 0300-9564. - 125:10(2018 Oct), pp. 1417-1432. [10.1007/s00702-018-1910-4]
Diagnostic biomarkers for Parkinson's disease at a glance : where are we?
A. Priori
2018
Abstract
Parkinson's disease (PD) is a neurodegenerative disorder whose aetiology remains unclear: degeneration involves several neurotransmission systems, resulting in a heterogeneous disease characterized by motor and non-motor symptoms. PD causes progressive disability that responds only to symptomatic therapies. Future advances include neuroprotective strategies for use in at-risk populations before the clinical onset of disease, hence the continuing need to identify reliable biomarkers that can facilitate the clinical diagnosis of PD. In this evaluative review, we summarize information on potential diagnostic biomarkers for use in the clinical and preclinical stages of PD.File | Dimensione | Formato | |
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10.1007_s00702-018-1910-4.pdf
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