In 28 postmenopausal women with rheumatoid arthritis, serum osteocalcin (OC) concentration decreased from 5.2±1.9 ng/ml to 3.0±1.6 ng/ml after 6 months therapy with corticosteroids (p<0.005). No differences, however, were found in a control group of 13 patients treated for 6 months with nonsteroidal anti-inflammatory drugs. In those patients with serial OC measurements, changes in serum OC were already evident within the first month of therapy. This suggests that a suppressed osteoblast function may be detectable early during corticosteroid therapy in rheumatoid arthritis. Fifteen patients treated with prednisone (5-25 mg once daily, mean 12.33 mg/day) showed a more marked decrease in serum OC than 13 patients treated with equivalent doses of deflazacort (p<0.005). Prednisone therapy at doses higher than 10 mg/day resulted in a severe suppression of OC values in most cases. The effect of deflazacort was, however, mild in the majority of patients treated with doses of up to 30 mg/day.
Serum Osteocalcin (bone Gla-protein) Following Corticosteroid-therapy In Postmenopausal Women With Rheumatoid-arthritis : comparison of the Effect of Prednisone and Deflazacort / C. Montecucco, F. Baldi, A. Fortina, G. Tomassini, R. Caporali, E.L. Cherieligniere, P. Fratino. - In: CLINICAL RHEUMATOLOGY. - ISSN 0770-3198. - 7:3(1988), pp. 366-371.
Serum Osteocalcin (bone Gla-protein) Following Corticosteroid-therapy In Postmenopausal Women With Rheumatoid-arthritis : comparison of the Effect of Prednisone and Deflazacort
R. Caporali;
1988
Abstract
In 28 postmenopausal women with rheumatoid arthritis, serum osteocalcin (OC) concentration decreased from 5.2±1.9 ng/ml to 3.0±1.6 ng/ml after 6 months therapy with corticosteroids (p<0.005). No differences, however, were found in a control group of 13 patients treated for 6 months with nonsteroidal anti-inflammatory drugs. In those patients with serial OC measurements, changes in serum OC were already evident within the first month of therapy. This suggests that a suppressed osteoblast function may be detectable early during corticosteroid therapy in rheumatoid arthritis. Fifteen patients treated with prednisone (5-25 mg once daily, mean 12.33 mg/day) showed a more marked decrease in serum OC than 13 patients treated with equivalent doses of deflazacort (p<0.005). Prednisone therapy at doses higher than 10 mg/day resulted in a severe suppression of OC values in most cases. The effect of deflazacort was, however, mild in the majority of patients treated with doses of up to 30 mg/day.Pubblicazioni consigliate
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