In order to identify rate and stability of remission induced by low-dose prednisone comedication in early rheumatoid arthritis (RA), we evaluated patients with early RA (<1 year) who were randomized to receive (P) or not (non-P) low-dose prednisone in association with step-up disease-modifying antirheumatic drug therapy over 2 years. Prevalence and duration of clinical remission were evaluated in the first and second year. Each treatment group included 105 patients; no significant differences were found at baseline. During the first year, P patients achieved higher rates of clinical remission with a time-averaged odds ratio (OR) of 1.965 (CI 95% 1.214-3.182, P= 0.006). Moreover, they showed a higher probability of sustained remission during the second year (OR 4.480, CI 95% 1.354-14.817, P= 0.014). In conclusion, we found as in early RA low-dose prednisone comedication is associated with higher rate of clinical remission, earlier disease activity control and more stable remission over time.

Early disease control by low-dose prednisone comedication may affect the quality of remission in patients with early rheumatoid arthritis / M. Todoerti, C.A. Scirè, N. Boffini, S. Bugatti, C. Montecucco, R. Caporali. - In: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. - ISSN 0077-8923. - 1193:(2010), pp. 139-145. [10.1111/j.1749-6632.2009.05367.x]

Early disease control by low-dose prednisone comedication may affect the quality of remission in patients with early rheumatoid arthritis

R. Caporali
Ultimo
2010

Abstract

In order to identify rate and stability of remission induced by low-dose prednisone comedication in early rheumatoid arthritis (RA), we evaluated patients with early RA (<1 year) who were randomized to receive (P) or not (non-P) low-dose prednisone in association with step-up disease-modifying antirheumatic drug therapy over 2 years. Prevalence and duration of clinical remission were evaluated in the first and second year. Each treatment group included 105 patients; no significant differences were found at baseline. During the first year, P patients achieved higher rates of clinical remission with a time-averaged odds ratio (OR) of 1.965 (CI 95% 1.214-3.182, P= 0.006). Moreover, they showed a higher probability of sustained remission during the second year (OR 4.480, CI 95% 1.354-14.817, P= 0.014). In conclusion, we found as in early RA low-dose prednisone comedication is associated with higher rate of clinical remission, earlier disease activity control and more stable remission over time.
early rheumatoid arthritis; low-dose glucocorticoids comedication; disease-modifying drugs; early disease activity control; clinical remission; longstanding clinical remission
Settore MED/16 - Reumatologia
2010
Article (author)
File in questo prodotto:
File Dimensione Formato  
Todoerti_et_al-2010-Annals_of_the_New_York_Academy_of_Sciences.pdf

accesso riservato

Tipologia: Publisher's version/PDF
Dimensione 152.8 kB
Formato Adobe PDF
152.8 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/664193
Citazioni
  • ???jsp.display-item.citation.pmc??? 12
  • Scopus 36
  • ???jsp.display-item.citation.isi??? 36
social impact