This study aimed to compare the performance of Fracture Risk Assessment Tool (FRAX) with that of Derived FRAX (DeFRA) in estimating fracture risk in a cohort of type-2 diabetes mellitus (T2DM) postmenopausal women. One hundred nineteen T2DM postmenopausal women and 118 consecutive healthy postmenopausal women were enrolled. Fracture risk was assessed with FRAX (adjusted or non- for trabecular bone score, TBS) and DeFRA. Bone mineral density (BMD) and TBS were evaluated by dual-energy X-ray absorptiometry (DXA). The outcome was the presence of vertebral/non-vertebral fragility fractures (FFs). T2DM women showed higher spinal BMD T-score (p <.05), but lower TBS (p <.05), than controls. Diabetic patients had higher prevalence of FFs compared to controls (p <.05), but no significant difference were found in the scores of any of the predictor tools. Differently, in the T2DM group, the scores of DeFRA, FRAX and adjusted-FRAX were significantly (p <.01 for all) higher in fractured compared with non-fractured women. DeFRA showed the best discriminative power among all fracture risk predictor tools (area under curves: DeFra: 0.89; adjusted FRAX: 0.80; non-adjusted FRAX: 0.73). In summary, all fracture risk assessment tools appeared to be effective in predicting bone fractures in T2DM postmenopausal women, with DeFRA showing a slightly better diagnostic accuracy.

Fracture risk assessment in postmenopausal women with diabetes : comparison between DeFRA and FRAX tools / G. Bonaccorsi, C. Messina, C. Cervellati, E. Maietti, M. Medini, M. Rossini, L. Massari, P. Greco. - In: GYNECOLOGICAL ENDOCRINOLOGY. - ISSN 0951-3590. - 34:5(2018 May), pp. 404-408. [10.1080/09513590.2017.1407308]

Fracture risk assessment in postmenopausal women with diabetes : comparison between DeFRA and FRAX tools

C. Messina
Secondo
;
2018

Abstract

This study aimed to compare the performance of Fracture Risk Assessment Tool (FRAX) with that of Derived FRAX (DeFRA) in estimating fracture risk in a cohort of type-2 diabetes mellitus (T2DM) postmenopausal women. One hundred nineteen T2DM postmenopausal women and 118 consecutive healthy postmenopausal women were enrolled. Fracture risk was assessed with FRAX (adjusted or non- for trabecular bone score, TBS) and DeFRA. Bone mineral density (BMD) and TBS were evaluated by dual-energy X-ray absorptiometry (DXA). The outcome was the presence of vertebral/non-vertebral fragility fractures (FFs). T2DM women showed higher spinal BMD T-score (p <.05), but lower TBS (p <.05), than controls. Diabetic patients had higher prevalence of FFs compared to controls (p <.05), but no significant difference were found in the scores of any of the predictor tools. Differently, in the T2DM group, the scores of DeFRA, FRAX and adjusted-FRAX were significantly (p <.01 for all) higher in fractured compared with non-fractured women. DeFRA showed the best discriminative power among all fracture risk predictor tools (area under curves: DeFra: 0.89; adjusted FRAX: 0.80; non-adjusted FRAX: 0.73). In summary, all fracture risk assessment tools appeared to be effective in predicting bone fractures in T2DM postmenopausal women, with DeFRA showing a slightly better diagnostic accuracy.
diabetes; fracture risk prediction; menopause; Osteoporosis; Absorptiometry, Photon; Aged; Bone Density; Diabetes Mellitus, Type 2; Female; Femoral Fractures; Humans; Incidence; Middle Aged; Osteoporotic Fractures; Postmenopause; Risk; Risk Assessment; Spinal Fractures
Settore MED/36 - Diagnostica per Immagini e Radioterapia
Settore MED/40 - Ginecologia e Ostetricia
mag-2018
24-nov-2017
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/663828
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