Background: We recently demonstrated that in premenopausal patients with estrogen receptors (ER)-absent tumors, early initiation of systemic chemotherapy after primary surgery might improve outcome. These data indicate a different responsiveness to chemotherapy for tumors not expressing hormone receptors. To test this hypothesis we evaluated the responsiveness to preoperative chemotherapy in patients with ER and progesterone receptors (PgR)-absent tumors. Patients and methods: Patients with biopsy-proven T2-T3, N0-2 breast cancer treated at a single institution from January 1995 to August 1999 with preoperative chemotherapy were retrospectively evaluated. ER and PgR were determined immunohistochemically and classified for this purpose as absent (0% of the cells positive) or positive (â¥ 1% of the cells). Results: On 117 evaluable patients 72 had an objective response (61%). A significant difference in response was observed for patients with ER and PgR absent compared with those with ER and/or PgR-positive tumors (82% vs. 57%, P = 0.03 Fishers's exact test). Pathological complete remission rates were also significantly different in the two groups (23% vs. 7%, respectively; P = 0.04). Conclusions: The different degree of response according to hormone receptors expression supports the hypothesis that tumors not expressing both ER and PgR might represent a different clinical entity in terms of chemotherapy responsiveness.
Response to primary chemotherapy in breast cancer patients with tumors not expressing estrogen and progesterone receptors / M. Colleoni, I. Minchella, G. Mazzarol, F. Nolè, G. Peruzzotti, A. Rocca, G. Viale, L. Orlando, G. Ferretti, G. Curigliano, P. Veronesi, M. Intra, A. Goldhirsch. - In: ANNALS OF ONCOLOGY. - ISSN 0923-7534. - 11:8(2000 Aug), pp. 1057-1059.
|Titolo:||Response to primary chemotherapy in breast cancer patients with tumors not expressing estrogen and progesterone receptors|
|Parole Chiave:||Breast cancer; Estrogen receptor; Preoperative chemotherapy; Progesterone receptor; Cancer Research; Oncology|
|Settore Scientifico Disciplinare:||Settore MED/06 - Oncologia Medica|
|Data di pubblicazione:||ago-2000|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1023/A:1008334404825|
|Appare nelle tipologie:||01 - Articolo su periodico|