A short-term evaluation of global skeletal uptake (GSU) of technetium-99m methylene diphosphonate (MDP) was performed in 40 healthy female subjects with a wide age range in order to investigate the clinical performance of the technique and to detect the age-related changes in bone turnover. The results obtained were compared with measurements of the main biochemical markers of skeletal metabolism. We found that GSU increases progressively with age, independently of concomitant changes in renal function; significant correlations with biochemical markers of bone formation were also found. Therefore, the method appears to provide useful information concerning the bone turnover rate, and is also applicable to elderly people owing to its simplicity.

Age-related changes in the global skeletal uptake of technetium-99m methylene diphosphonate in healthy women / V. Carnevale, V. Frusciante, A. Scillitani, S. Modoni, M. Pileri, I. Chiodini, F. Dicembrino, E. Romagnoli, S. Minisola. - In: EUROPEAN JOURNAL OF NUCLEAR MEDICINE. - ISSN 0340-6997. - 23:11(1996 Nov), pp. 1473-1477.

Age-related changes in the global skeletal uptake of technetium-99m methylene diphosphonate in healthy women

I. Chiodini;
1996

Abstract

A short-term evaluation of global skeletal uptake (GSU) of technetium-99m methylene diphosphonate (MDP) was performed in 40 healthy female subjects with a wide age range in order to investigate the clinical performance of the technique and to detect the age-related changes in bone turnover. The results obtained were compared with measurements of the main biochemical markers of skeletal metabolism. We found that GSU increases progressively with age, independently of concomitant changes in renal function; significant correlations with biochemical markers of bone formation were also found. Therefore, the method appears to provide useful information concerning the bone turnover rate, and is also applicable to elderly people owing to its simplicity.
bone turnover; global skeletal uptake; aging
Settore MED/13 - Endocrinologia
nov-1996
Article (author)
File in questo prodotto:
File Dimensione Formato  
04 - Age-related changes in the GSU of 99mTC diphosphonate in healthy women - Eur J Nucl Med 1996.pdf

accesso riservato

Tipologia: Publisher's version/PDF
Dimensione 894.23 kB
Formato Adobe PDF
894.23 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/663610
Citazioni
  • ???jsp.display-item.citation.pmc??? 2
  • Scopus 20
  • ???jsp.display-item.citation.isi??? 18
social impact