Many lymphoma and myeloma patients fail to undergo ASCT owing to poor mobilization. Identification of poor mobilizers (PMs) would provide a tool for early intervention with new mobilization agents. The Gruppo italianoTrapianto di Midollo Osseo working group proposed a definition of PMs applicable to clinical trials and clinical practice. The analytic hierarchy process, a method for group decision making, was used in setting prioritized criteria. Lymphoma or myeloma patients were defined as 'proven PM' when: (1) after adequate mobilization (G-CSF 10 μg/kg if used alone or 5 μg/kg after chemotherapy) circulating CD34(+) cell peak is <20/μL up to 6 days after mobilization with G-CSF or up to 20 days after chemotherapy and G-CSF or (2) they yielded <2.0 × 10(6) CD34(+) cells per kg in 3 apheresis. Patients were defined as predicted PMs if: (1) they failed a previous collection attempt (not otherwise specified); (2) they previously received extensive radiotherapy or full courses of therapy affecting SC mobilization; and (3) they met two of the following criteria: advanced disease (2 lines of chemotherapy), refractory disease, extensive BM involvement or cellularity <30% at the time of mobilization; age 65 years. This definition of proven and predicted PMs should be validated in clinical trials and common clinical practice.
Proposed definition of 'poor mobilizer' in lymphoma and multiple myeloma: an analytic hierarchy process by ad hoc working group Gruppo ItalianoTrapianto di Midollo Osseo / A. Olivieri, M. Marchetti, R. Lemoli, C. Tarella, A. Iacone, F. Lanza, A. Rambaldi, A. Bosi. - In: BONE MARROW TRANSPLANTATION. - ISSN 0268-3369. - 47:3(2012), pp. 342-351.
|Titolo:||Proposed definition of 'poor mobilizer' in lymphoma and multiple myeloma: an analytic hierarchy process by ad hoc working group Gruppo ItalianoTrapianto di Midollo Osseo|
|Parole Chiave:||stem cell mobilization; autologous transplantation; consensus conference; lymphoma; multiple myeloma|
|Settore Scientifico Disciplinare:||Settore MED/15 - Malattie del Sangue|
|Data di pubblicazione:||2012|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1038/bmt.2011.82|
|Appare nelle tipologie:||01 - Articolo su periodico|