Many scientific works indicate that exercise can counteract the effects of neurological diseases. The positive role of exercise in both healthy and pathological individuals was recently brought to light when it was demonstrated that Alzheimer’s patients regained some of their brain capabilities after appropriate and controlled physical training [1]. On the other hand, we can hypothesize that the absence, or reduction, of movements - especially those with antigravity effects - could induce deterioration of the brain. Adult neurogenesis is restricted to few areas of the mammalian brain: the sub-ventricular zone of the lateral ventricles (SVZ), the sub-granular zone of the dentate gyrus of the hippocampus and the spinal cord [2]. Low levels of exercise are thought to represent a major risk factor of developing metabolic alteration [3] that could affect the central nervous system and in particular some neurogenic areas [4, 5]. Our analysis shows that NSCs derived from the SVZ of motor deprived (HU) mice have a reduced proliferation capability and an altered cell cycle. Furthermore, Neural Stem Cells (NSCs) obtained from HU animals present an incomplete differentiation/maturation. The results of this work support the existence of a link between the reduction of exercise and muscle disuse and metabolism in the brain. Indeed, it represents valuable new information that could clarify how circumstances such as the absence of load and the lack of movement that occurs in people with some neurological diseases, may affect the properties of NSCs and contribute to the negative manifestations of these conditions. Biography: 1) Okonkwo, O. C. et al. AD. Neurology 83, 1753-1760, doi:10.1212/WNL.0000000000000964 (2014). 2) Bottai, D. et al. Journal of hematotherapy & stem cell research 12, 655-670 (2003). 3) Laaksonen, D. E. et al.. Diabetes Care 25, 1612-1618 (2002). 4) Bottai, D. & Adami, R. Brain pathology 23, 613-622, doi:10.1111/bpa.12071 (2013). 5) Adami, R. & Bottai, D. Journal of neuroscience research 94, 310-317, doi:10.1002/jnr.23711 (2016).

Reduction Of Movement In Neurological Diseases: Effects On Neurogenesis / D. Bottai. ((Intervento presentato al 4. convegno Global Cell Science and Stem Cell Conference-2019 (CSSC-2019) Co-Chairman section: Exploring New Strategies for Research and Therapeutic Innovation tenutosi a Prague nel 2019.

Reduction Of Movement In Neurological Diseases: Effects On Neurogenesis

D. Bottai
Conceptualization
2019

Abstract

Many scientific works indicate that exercise can counteract the effects of neurological diseases. The positive role of exercise in both healthy and pathological individuals was recently brought to light when it was demonstrated that Alzheimer’s patients regained some of their brain capabilities after appropriate and controlled physical training [1]. On the other hand, we can hypothesize that the absence, or reduction, of movements - especially those with antigravity effects - could induce deterioration of the brain. Adult neurogenesis is restricted to few areas of the mammalian brain: the sub-ventricular zone of the lateral ventricles (SVZ), the sub-granular zone of the dentate gyrus of the hippocampus and the spinal cord [2]. Low levels of exercise are thought to represent a major risk factor of developing metabolic alteration [3] that could affect the central nervous system and in particular some neurogenic areas [4, 5]. Our analysis shows that NSCs derived from the SVZ of motor deprived (HU) mice have a reduced proliferation capability and an altered cell cycle. Furthermore, Neural Stem Cells (NSCs) obtained from HU animals present an incomplete differentiation/maturation. The results of this work support the existence of a link between the reduction of exercise and muscle disuse and metabolism in the brain. Indeed, it represents valuable new information that could clarify how circumstances such as the absence of load and the lack of movement that occurs in people with some neurological diseases, may affect the properties of NSCs and contribute to the negative manifestations of these conditions. Biography: 1) Okonkwo, O. C. et al. AD. Neurology 83, 1753-1760, doi:10.1212/WNL.0000000000000964 (2014). 2) Bottai, D. et al. Journal of hematotherapy & stem cell research 12, 655-670 (2003). 3) Laaksonen, D. E. et al.. Diabetes Care 25, 1612-1618 (2002). 4) Bottai, D. & Adami, R. Brain pathology 23, 613-622, doi:10.1111/bpa.12071 (2013). 5) Adami, R. & Bottai, D. Journal of neuroscience research 94, 310-317, doi:10.1002/jnr.23711 (2016).
22-giu-2019
Neurogenesis; reduction of movement; Neural Stem Cells; Hind limb unloading.
Settore BIO/13 - Biologia Applicata
Settore BIO/14 - Farmacologia
Settore BIO/09 - Fisiologia
Settore BIO/11 - Biologia Molecolare
http://www.pcscongress.com/cssc2019/article.asp?articleid=152
Reduction Of Movement In Neurological Diseases: Effects On Neurogenesis / D. Bottai. ((Intervento presentato al 4. convegno Global Cell Science and Stem Cell Conference-2019 (CSSC-2019) Co-Chairman section: Exploring New Strategies for Research and Therapeutic Innovation tenutosi a Prague nel 2019.
Conference Object
File in questo prodotto:
File Dimensione Formato  
Abstract-PCS CSSC-2019-Bottai-Daniele.pdf

accesso aperto

Tipologia: Pre-print (manoscritto inviato all'editore)
Dimensione 77.85 kB
Formato Adobe PDF
77.85 kB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/663011
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact