8-p-Nitrocinnamyl-3-propionyl-3,8-diazabicyclo[3.2.1]octane (2b) and its isomer (1b), having the nitrogen substituents exchanged, have been compared by X-Ray structural analysis. The different orientation of the cinnamyl chain in the two derivatives has been discussed and related to the pharmacological properties.
A structural and conformational study of 8-p-nitrocinnamyl-3-propionyl-3,8-diazabicyclo[3.2.1]-octane, selective agonist of μ-opioid receptors / R. Artali, D. Barlocco, G. Bombieri, F. Meneghetti. - In: HETEROCYCLES. - ISSN 0385-5414. - 57:3(2002), pp. 439-447. [10.3987/COM-01-9398]
A structural and conformational study of 8-p-nitrocinnamyl-3-propionyl-3,8-diazabicyclo[3.2.1]-octane, selective agonist of μ-opioid receptors
R. ArtaliPrimo
;D. BarloccoSecondo
;G. BombieriPenultimo
;F. MeneghettiUltimo
2002
Abstract
8-p-Nitrocinnamyl-3-propionyl-3,8-diazabicyclo[3.2.1]octane (2b) and its isomer (1b), having the nitrogen substituents exchanged, have been compared by X-Ray structural analysis. The different orientation of the cinnamyl chain in the two derivatives has been discussed and related to the pharmacological properties.
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